ENSDARG00000060766


Danio rerio

Features
Gene ID: ENSDARG00000060766
  
Biological name :pxnb
  
Synonyms : paxillin b / pxnb
  
Possible biological names infered from orthology : P49023 / paxillin / PXN / Q8VI36
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 3496204
Gene end: 3519152
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080428
swissprot - E7F7U1
ZFIN ID - ZDB-GENE-130530-697
Ensembl - ENSDARG00000060766
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PXNENSGALG00000007247Gallus gallus
 PXNENSG00000089159Homo sapiens
 PxnENSMUSG00000029528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pxna / paxillin a / PXN* / P49023* / Q8VI36* / paxillin*ENSDARG0000008859073
lpxn / leupaxin / O60711* / Q99N69*ENSDARG0000007931534
pdlim5b / PDZ and LIM domain 5b / PDLIM5* / Q96HC4* / PDZ and LIM domain 5*ENSDARG0000002760018
ldb3a / LIM domain binding 3a / LDB3* / O75112* / Q9JKS4* / LIM domain binding 3* / LIM domain-binding protein 3 *ENSDARG0000005632218
pdlim5a / PDZ and LIM domain 5a / PDLIM5* / Q8CI51* / Q96HC4* / PDZ and LIM domain 5* / PDZ and LIM domain protein 5 *ENSDARG0000010177718
CABZ01078593.1 / Q3TJD7* / PDLIM7* / Q9NR12* / PDZ and LIM domain 7* / PDZ and LIM domain protein 7 *ENSDARG0000010385415
fhl2b / four and a half LIM domains 2b / FHL2* / O70433* / Q14192* / four and a half LIM domains 2* / Four and a half LIM domains protein 2 *ENSDARG0000000399113
lims1 / LIM and senescent cell antigen-like domains 1 / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / AC013271.1* / AC112229.3* / LIM zinc finger domain containing 4* / LIM zinc finger do...ENSDARG0000002698513
fhl3a / four and a half LIM domains 3a / FHL3* / Q13643* / Q9R059* / four and a half LIM domains 3* / Four and a half LIM domains protein 3 *ENSDARG0000003464313
fhl2a / four and a half LIM domains 2a / FHL2* / O70433* / Q14192* / four and a half LIM domains 2* / Four and a half LIM domains protein 2 *ENSDARG0000004201813
fhl5 / four and a half LIM domains 5 / Q5TD97* / Q9WTX7* / Four and a half LIM domains protein 5 *ENSDARG0000001480512
lims2 / LIM and senescent cell antigen-like domains 2 / LIMS3* / LIMS4* / LIMS1* / P48059* / P0CW19* / P0CW20* / AC013271.1* / AC112229.3* / LIM zinc finger domain containing 3* / LIM zinc ...ENSDARG0000001497612
fhl3b / four and a half LIM domains 3b / FHL3* / Q13643* / Q9R059* / four and a half LIM domains 3* / Four and a half LIM domains protein 3 *ENSDARG0000010431512
fhl1b / four and a half LIM domains 1b / FHL1* / Fhl4* / Q13642* / P97447* / four and a half LIM domains 1* / Four and a half LIM domains protein 1 *ENSDARG0000005665311
fhl1a / four and a half LIM domains 1a / FHL1* / Fhl4* / Q13642* / P97447* / four and a half LIM domains 1* / Four and a half LIM domains protein 1 *ENSDARG0000007149810
ldb3b / LIM domain binding 3bENSDARG000000999744


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR001904  Paxillin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0061055 myotome development IGI
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle decreased volume , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000135 notochord notochord malformed , abnormal
Show

 ZFA:0000471 atrium atrium decreased volume , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum decreased amount , abnormal
Show

 ZFA:0001056 myotome myotome malformed , abnormal
myotome muscle tendon junction decreased amount , abnormal
myotome muscle tendon junction increased amount , abnormal
myotome muscle tendon junction increased distribution , abnormal
myotome muscle cell increased length , abnormal
myotome muscle cell detached from myotome muscle tendon junction, abnormal
Show

 ZFA:0001094 whole organism whole organism absent , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region notochord kinked , abnormal
Show

 ZFA:0005744 notochord outer sheath cell notochord outer sheath cell mislocalised , abnormal
notochord outer sheath cell cytoplasm mislocalised , abnormal
notochord outer sheath cell cell-cell junction mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr