ENSDARG00000061351


Danio rerio

Features
Gene ID: ENSDARG00000061351
  
Biological name :tfpi2
  
Synonyms : tfpi2 / tissue factor pathway inhibitor 2
  
Possible biological names infered from orthology : O35536 / P48307
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 40848109
Gene end: 40855106
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000081855
NCBI entrez gene - 560339     See in Manteia.
RefSeq - NM_001040096
RefSeq Peptide - NP_001035185
swissprot - Q1WCN6
ZFIN ID - ZDB-GENE-060503-38
Ensembl - ENSDARG00000061351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFPI2ENSGALG00000009512Gallus gallus
 TFPI2ENSG00000105825Homo sapiens
 Tfpi2ENSMUSG00000029664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tfpia / tissue factor pathway inhibitor a / TFPI* / P10646* / O54819* / tissue factor pathway inhibitor*ENSDARG0000003471832
spint2 / serine peptidase inhibitor, Kunitz type, 2 / O43291* / Q9WU03* / AC011479.1* / Kunitz-type protease inhibitor 2 *ENSDARG0000006947628
spint1a / serine peptidase inhibitor, Kunitz type 1 a / O43278* / SPINT1* / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000010233224
spint1b / serine peptidase inhibitor, Kunitz type 1 b / O43278* / Q9R097* / SPINT1* / Kunitz-type protease inhibitor 1 * / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000001246722
wfikkn2a / info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a / Q8TEU8* / Q7TQN3* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin dom...ENSDARG0000001346018
ambp / alpha-1-microglobulin/bikunin precursor / P02760* / Q07456* / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin*ENSDARG0000000429617
wfikkn2b / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b / Q7TQN3* / Q8TEU8* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain c...ENSDARG0000005913917
wfikkn1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / Q96NZ8*ENSDARG0000010136417


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:1903706 regulation of hemopoiesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary malformed , abnormal
midbrain hindbrain boundary nerve sparse , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk increased size , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle decreased size , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
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 ZFA:0000152 retina retina photoreceptor cell disorganized , abnormal
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 ZFA:0000161 third ventricle third ventricle decreased size , abnormal
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 ZFA:0000471 atrium atrium dilated , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal malformed , abnormal
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 ZFA:0009147 glial cell (sensu Vertebrata) glial cell (sensu Vertebrata) decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte hemoglobin complex decreased amount , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell Z disc disorganized , abnormal
cardiac muscle cell sarcomere organization disrupted , abnormal
cardiac muscle cell cardiac myofibril decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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