ENSDARG00000034718


Danio rerio

Features
Gene ID: ENSDARG00000034718
  
Biological name :tfpia
  
Synonyms : tfpia / tissue factor pathway inhibitor a
  
Possible biological names infered from orthology : O54819 / P10646 / TFPI / tissue factor pathway inhibitor
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 42420636
Gene end: 42484448
  
Corresponding Affymetrix probe sets: Dr.20029.1.A1_at (Zebrafish Array)   DrAffx.1.27.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000047652
Ensembl peptide - ENSDARP00000048319
NCBI entrez gene - 359833     See in Manteia.
RefSeq - NM_001309803
RefSeq - NM_182872
RefSeq Peptide - NP_001296732
RefSeq Peptide - NP_878292
swissprot - B0S6C1
swissprot - E7EXD1
ZFIN ID - ZDB-GENE-030711-1
Ensembl - ENSDARG00000034718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFPIENSGALG00000002594Gallus gallus
 TFPIENSG00000003436Homo sapiens
 TfpiENSMUSG00000027082Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tfpi2 / tissue factor pathway inhibitor 2 / O35536* / P48307*ENSDARG0000006135127
spint2 / serine peptidase inhibitor, Kunitz type, 2 / O43291* / Q9WU03* / AC011479.1* / Kunitz-type protease inhibitor 2 *ENSDARG0000006947625
spint1a / serine peptidase inhibitor, Kunitz type 1 a / O43278* / SPINT1* / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000010233220
spint1b / serine peptidase inhibitor, Kunitz type 1 b / O43278* / Q9R097* / SPINT1* / Kunitz-type protease inhibitor 1 * / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000001246719
ambp / alpha-1-microglobulin/bikunin precursor / P02760* / Q07456* / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin*ENSDARG0000000429615
wfikkn2b / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b / Q7TQN3* / Q8TEU8* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain c...ENSDARG0000005913915
wfikkn1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / Q96NZ8*ENSDARG0000010136415
wfikkn2a / info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a / Q8TEU8* / Q7TQN3* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin dom...ENSDARG0000001346014


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005673 f3b / coagulation factor IIIb / F3* / P13726* / coagulation factor III, tissue factor*  / reaction / complex
 ENSDARG00000088581 f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*  / reaction / complex
 ENSDARG00000099124 f3a / coagulation factor IIIa / F3* / P13726* / coagulation factor III, tissue factor*  / reaction / complex
 ENSDARG00000100782 zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*  / reaction / complex






 

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