ENSDARG00000062562


Danio rerio

Features
Gene ID: ENSDARG00000062562
  
Biological name :egln2
  
Synonyms : egl-9 family hypoxia-inducible factor 2 / egln2
  
Possible biological names infered from orthology : AC008537.1 / Egl nine homolog 2 / Q91YE2 / Q96KS0
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 8335600
Gene end: 8382997
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000126905
Ensembl peptide - ENSDARP00000152746
NCBI entrez gene - 559569     See in Manteia.
swissprot - E7F8S1
ZFIN ID - ZDB-GENE-060503-757
Ensembl - ENSDARG00000062562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC008537.1ENSG00000268797Homo sapiens
 EGLN2ENSG00000269858Homo sapiens
 Egln2ENSMUSG00000058709Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*ENSDARG0000000463233
egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*ENSDARG0000003899632
egln3 / egl-9 family hypoxia-inducible factor 3 / Q9H6Z9*ENSDARG0000003255326
egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*ENSDARG0000010515613


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000100826 hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*  / reaction






 

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