ENSDARG00000070173


Danio rerio

Features
Gene ID: ENSDARG00000070173
  
Biological name :gria2a
  
Synonyms : glutamate receptor, ionotropic, AMPA 2a / gria2a
  
Possible biological names infered from orthology : glutamate ionotropic receptor AMPA type subunit 2 / glutamate receptor 2 isoform 3 / GRIA2 / P42262
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 21333068
Gene end: 21409877
  
Corresponding Affymetrix probe sets: Dr.18279.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072271
Ensembl peptide - ENSDARP00000093557
swissprot - B0V2X4
swissprot - B0V2X6
ZFIN ID - ZDB-GENE-020125-3
Ensembl - ENSDARG00000070173
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRIA2ENSGALG00000009405Gallus gallus
 GRIA2ENSG00000120251Homo sapiens
 Gria2ENSMUSG00000033981Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gria2b / glutamate receptor, ionotropic, AMPA 2b / GRIA2* / P42262* / glutamate receptor 2 isoform 3 * / glutamate ionotropic receptor AMPA type subunit 2*ENSDARG0000005276590
gria4b / glutamate receptor, ionotropic, AMPA 4bENSDARG0000005936871
gria4a / glutamate receptor, ionotropic, AMPA 4aENSDARG0000003749670
gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...ENSDARG0000003749870
gria3a / glutamate receptor, ionotropic, AMPA 3a / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...ENSDARG0000003273769
gria1a / glutamate receptor, ionotropic, AMPA 1a / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*ENSDARG0000002135267
gria1b / glutamate receptor, ionotropic, AMPA 1b / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*ENSDARG0000003271466
GRIK2 / glutamate ionotropic receptor kainate type subunit 2 / P39087* / Q13002* / Glutamate receptor ionotropic, kainate 2 *ENSDARG0000011377139
grik1b / glutamate receptor, ionotropic, kainate 1b / GRIK1* / P39086* / glutamate ionotropic receptor kainate type subunit 1* / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik...ENSDARG0000004062738
grik1a / glutamate receptor, ionotropic, kainate 1a / GRIK1* / P39086* / glutamate ionotropic receptor kainate type subunit 1* / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik...ENSDARG0000006913937
GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / Q13003*ENSDARG0000007771536
grik4 / glutamate receptor, ionotropic, kainate 4 / Q16099* / Q8BMF5* / glutamate ionotropic receptor kainate type subunit 4*ENSDARG0000002675335
grik5 / glutamate receptor, ionotropic, kainate 5 / Q16478* / Q61626* / glutamate ionotropic receptor kainate type subunit 5*ENSDARG0000010144934
grid1a / glutamate receptor, ionotropic, delta 1a / GRID1* / Q61627* / Q9ULK0* / Glutamate receptor ionotropic, delta-1 * / glutamate ionotropic receptor delta type subunit 1*ENSDARG0000007458327
grid1b / glutamate receptor, ionotropic, delta 1b / GRID1* / Q61627* / Q9ULK0* / Glutamate receptor ionotropic, delta-1 * / glutamate ionotropic receptor delta type subunit 1*ENSDARG0000004416126
grid2 / glutamate receptor, ionotropic, delta 2 / O43424* / Q61625* / glutamate ionotropic receptor delta type subunit 2*ENSDARG0000005530224
grin1b / glutamate receptor, ionotropic, N-methyl D-aspartate 1b / GRIN1* / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 * / glutamate ionotropic receptor NMDA type subunit 1*ENSDARG0000002572821
grin1a / glutamate receptor, ionotropic, N-methyl D-aspartate 1a / GRIN1* / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 * / glutamate ionotropic receptor NMDA type subunit 1*ENSDARG0000002782821
grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...ENSDARG0000003037621
grin2aa / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*ENSDARG0000003449320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001638  Solute-binding protein family 3/N-terminal domain of MltF
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048899 anterior lateral line development IMP
 biological_processGO:0048915 posterior lateral line system development IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Activation of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain apoptotic process increased process quality , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type motor neuron , abnormal
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 ZFA:0000107 eye eye apoptotic process increased process quality , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000128 midbrain midbrain apoptotic process increased process quality , abnormal
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 ZFA:0000161 third ventricle third ventricle increased size , abnormal
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 ZFA:0000671 horizontal myoseptum horizontal myoseptum apoptotic process increased process quality , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head apoptotic process increased process quality , abnormal
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 ZFA:0001115 trunk trunk apoptotic process increased process quality , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch absent , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula decreased size , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage absent , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage malformed , abnormal
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 ZFA:0001472 anterior lateral line neuromast anterior lateral line neuromast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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