ENSDARG00000074740


Danio rerio
rhoarhgap18proteingtpasegtpase-activatingdomainactivationsignaltransductionregulationsproutingangiogenesiscycledorsalaortahindbrainpericardiumyolkintersegmentalvessel

Features
Gene ID: ENSDARG00000074740
  
Biological name :arhgap18
  
Synonyms : arhgap18 / Rho GTPase activating protein 18
  
Possible biological names infered from orthology : Q8K0Q5 / Q8N392
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 2064400
Gene end: 2090789
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000100615
swissprot - E7F5Q5
ZFIN ID - ZDB-GENE-070502-1
Ensembl - ENSDARG00000074740
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGAP18ENSGALG00000031843Gallus gallus
 Q8N392ENSG00000146376Homo sapiens
 Q8K0Q5ENSMUSG00000039031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dlc1 / DLC1 Rho GTPase activating protein / Q96QB1*ENSDARG0000007931718
stard13b / StAR-related lipid transfer (START) domain containing 13b / Q9Y3M8* / Q923Q2* / STARD13* / StAR-related lipid transfer protein 13 * / StAR related lipid transfer domain containing 13*ENSDARG0000009895418
arhgap28 / Rho GTPase activating protein 28 / Q9P2N2*ENSDARG0000010135018
si:dkeyp-23e4.3ENSDARG0000007481917
stard8 / StAR-related lipid transfer (START) domain containing 8 / Q92502* / Q8K031* / StAR-related lipid transfer protein 8 * / StAR related lipid transfer domain containing 8*ENSDARG0000001400316
arhgap36 / Rho GTPase activating protein 36ENSDARG0000005967216
stard13a / StAR-related lipid transfer (START) domain containing 13a / Q9Y3M8* / Q923Q2* / STARD13* / StAR-related lipid transfer protein 13 * / StAR related lipid transfer domain containing 13*ENSDARG0000007954216
arhgap11a / Rho GTPase activating protein 11A / Q3KRB8* / Q6P4F7* / Q80Y19* / ARHGAP11B* / AC091057.5* / Rho GTPase activating protein 11B*ENSDARG0000010001913
zgc:153345ENSDARG0000005562212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
cell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcellular response to stimulusanatomical structure developmentcell communicationcell communicationcellular response to stimuluscellular response to stimulusanatomical structure developmentanatomical structure development
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IMP


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
Show

 ZFA:0000029 hindbrain hindbrain edematous , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel increased length , abnormal
intersegmental vessel has extra parts of type endothelial cell filopodium, abnormal
intersegmental vessel sprouting angiogenesis increased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr