ENSDARG00000076020


Danio rerio

Features
Gene ID: ENSDARG00000076020
  
Biological name :pappa2
  
Synonyms : pappa2 / pappalysin 2
  
Possible biological names infered from orthology : Q9BXP8
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 34986201
Gene end: 35103069
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000104154
NCBI entrez gene - 567038     See in Manteia.
RefSeq - XM_009298646
RefSeq - XM_690325
swissprot - E9QCK7
ZFIN ID - ZDB-GENE-070912-525
Ensembl - ENSDARG00000076020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040432Gallus gallus
 PAPPA2ENSG00000116183Homo sapiens
 Pappa2ENSMUSG00000073530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pappaa / pregnancy-associated plasma protein A, pappalysin 1a / PAPPA* / Q8R4K8* / Q13219* / pappalysin 1*ENSDARG0000010109040
pappab / pregnancy-associated plasma protein A, pappalysin 1b / PAPPA* / Q8R4K8* / Q13219* / pappalysin 1*ENSDARG0000005985839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR026918  Pappalysin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0051216 cartilage development IMP
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction
 ENSDARG00000039264 igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction
 ENSDARG00000025348 igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr