ENSDARG00000076058


Danio rerio

Features
Gene ID: ENSDARG00000076058
  
Biological name :gba
  
Synonyms : gba / glucosidase, beta, acid
  
Possible biological names infered from orthology : Glucosylceramidase / glucosylceramidase beta / P04062 / P17439
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 14216581
Gene end: 14231312
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000098103
NCBI entrez gene - 559072     See in Manteia.
RefSeq - XM_682379
swissprot - E7EZM1
ZFIN ID - ZDB-GENE-100922-270
Ensembl - ENSDARG00000076058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GBAENSG00000177628Homo sapiens
 GbaENSMUSG00000028048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001139  Glycoside hydrolase family 30
 IPR017853  Glycoside hydrolase superfamily
 IPR033452  Glycosyl hydrolase family 30, beta sandwich domain
 IPR033453  Glycosyl hydrolase family 30, TIM-barrel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006680 glucosylceramide catabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0036268 swimming IMP
 biological_processGO:0070050 neuron cellular homeostasis IMP
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004348 glucosylceramidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased amount , abnormal
brain cytochrome-c oxidase activity decreased process quality , abnormal
brain chitinase activity increased process quality , abnormal
brain mitochondrion decreased functionality , abnormal
brain autophagosome increased amount , abnormal
brain ubiquinol-cytochrome-c reductase activity decreased process quality , abnormal
brain hexosaminidase activity increased process quality , abnormal
brain glial cell projection retracted , abnormal
brain microglial cell circular , abnormal
brain macrophage morphology , abnormal
brain macrophage increased amount , abnormal
brain increased amount , abnormal
Show

 ZFA:0000075 spinal cord spinal cord curved , abnormal
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 ZFA:0000123 liver liver increased size , abnormal
liver macrophage morphology , abnormal
liver macrophage increased amount , abnormal
Show

 ZFA:0000126 centrum centrum bone mineralization decreased occurrence , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle macrophage increased size , abnormal
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 ZFA:0000250 opercle opercle decreased volume , abnormal
opercle bone mineralization decreased occurrence , abnormal
Show

 ZFA:0000324 caudal periventricular hypothalamus caudal periventricular hypothalamus dopaminergic neuron decreased amount , abnormal
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 ZFA:0000436 spleen spleen increased size , abnormal
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 ZFA:0000578 ceratohyal bone ceratohyal bone bone mineralization decreased occurrence , abnormal
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 ZFA:0000633 caudal tuberculum caudal tuberculum dopaminergic neuron decreased amount , abnormal
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 ZFA:0000737 cranium cranium bone mineralization decreased occurrence , abnormal
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 ZFA:0001078 thymus thymus macrophage morphology , abnormal
thymus macrophage increased amount , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism increased amount , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0005023 hematopoietic system hematopoietic system has fewer parts of type thrombocyte , abnormal
hematopoietic system has fewer parts of type nucleate erythrocyte , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell mislocalised , abnormal
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 ZFA:0009067 CNS neuron (sensu Vertebrata) CNS neuron (sensu Vertebrata) inclusion body increased amount , abnormal
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 ZFA:0009077 microglial cell microglial cell increased accumulation brain , abnormal
microglial cell spherical , abnormal
microglial cell vacuole increased amount , abnormal
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 ZFA:0009141 macrophage macrophage increased accumulation tectal ventricle , abnormal
macrophage morphology , abnormal
macrophage lysosome accumulation macrophage , abnormal
macrophage myeloid leukocyte migration process quality , abnormal
macrophage myeloid leukocyte migration decreased process quality , abnormal
macrophage endocytic recycling decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000013968 psap / prosaposin / Q6NUJ1* / P07602* / PSAPL1* / Q61207* / prosaposin-like 1* / prosaposin like 1 (gene/pseudogene)*  / complex






 

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