ENSDARG00000090637


Danio rerio

Features
Gene ID: ENSDARG00000090637
  
Biological name :myh6
  
Synonyms : myh6 / myosin, heavy chain 6, cardiac muscle, alpha
  
Possible biological names infered from orthology : MYH7 / Myosin-7 / myosin heavy chain 6 / myosin heavy chain 7 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P12883 / P13533 / Q02566 / Q91Z83
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 53577502
Gene end: 53583436
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000108536
NCBI entrez gene - 386711     See in Manteia.
RefSeq - NM_198823
RefSeq Peptide - NP_942118
swissprot - B8JLS3
ZFIN ID - ZDB-GENE-031112-1
Ensembl - ENSDARG00000090637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYH7ENSGALG00000035594Gallus gallus
 MYH6ENSG00000197616Homo sapiens
 MYH7ENSG00000092054Homo sapiens
 Myh6ENSMUSG00000040752Mus musculus
 Myh7ENSMUSG00000053093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smyhc1 / slow myosin heavy chain 1 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000009995984
smyhc2 / slow myosin heavy chain 2 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000010396984
myh7 / myosin heavy chain 7 / MYH6* / Q91Z83* / P12883* / P13533* / Q02566* / Myosin-7 * / myosin heavy chain 6* / myosin, heavy polypeptide 6, cardiac muscle, alpha*ENSDARG0000007956483
CU633479.2 / MYH6* / MYH7* / P13533* / P12883* / myosin heavy chain 6* / myosin heavy chain 7*ENSDARG0000010383783
smyhc2 / slow myosin heavy chain 2 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000011403183
myh7l / myosin heavy chain 7-like / MYH6* / MYH7* / Q91Z83* / P12883* / P13533* / Q02566* / Myosin-7 * / myosin heavy chain 7* / myosin heavy chain 6* / myosin, heavy polypeptide 6, cardiac...ENSDARG0000007978282
myhb / myosin, heavy chain b / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1 * / Myosin-8 * / Myosin-4 * ...ENSDARG0000000199376
myhz2 / myosin, heavy polypeptide 2, fast muscle specific / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1...ENSDARG0000001294476
myhz1.3 / myosin, heavy polypeptide 1.3, skeletal muscle / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1 ...ENSDARG0000006799776
myh7ba / myosin, heavy chain 7B, cardiac muscle, beta a / MYH7B* / A7E2Y1* / A2AQP0* / Myosin-7B * / myosin heavy chain 7B*ENSDARG0000007607571
myh7bb / myosin, heavy chain 7B, cardiac muscle, beta b / MYH7B* / A7E2Y1* / A2AQP0* / Myosin-7B * / myosin heavy chain 7B*ENSDARG0000003532269
myhz1.1 / myosin, heavy polypeptide 1.1, skeletal muscle / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / Q9UKX2* / Q9UKX3* / myosin heavy chain 1* / myosin heavy ch...ENSDARG0000010241464
CU633479.1 / MYH6* / MYH7* / P13533* / P12883* / myosin heavy chain 6* / myosin heavy chain 7*ENSDARG0000009874761
myh11a / myosin, heavy chain 11a, smooth muscle / MYH11* / P35749* / myosin heavy chain 11*ENSDARG0000000978239
myh10 / myosin, heavy chain 10, non-muscle / Q61879* / P35580* / Myosin-10 * / myosin heavy chain 10*ENSDARG0000000010338
myh9a / myosin, heavy chain 9a, non-muscle / MYH9* / P35579* / Q8VDD5* / myosin heavy chain 9* / myosin, heavy polypeptide 9, non-muscle*ENSDARG0000006329538
myh14 / myosin, heavy chain 14, non-muscle / Q7Z406* / Q6URW6* / Myosin-14 * / myosin heavy chain 14*ENSDARG0000007373238
myh11b / myosin, heavy chain 11b, smooth muscle / MYH11* / P35749* / myosin heavy chain 11*ENSDARG0000010097237
myh9b / myosin, heavy chain 9b, non-muscle / MYH9* / P35579* / Q8VDD5* / myosin heavy chain 9* / myosin, heavy polypeptide 9, non-muscle*ENSDARG0000000101435
CABZ01079179.1 / MYH8* / MYH1* / MYH2* / MYH4* / MYH13* / Q9Y623* / P12882* / P13535* / Q9UKX2* / Q9UKX3* / myosin heavy chain 1* / myosin heavy chain 2* / myosin heavy chain 4* / myosin he...ENSDARG0000011059622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003230 cardiac atrium development IMP
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0055004 atrial cardiac myofibril assembly IMP
 biological_processGO:0060047 heart contraction IMP
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation sinus venosus , abnormal
blood accumulation atrium , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
cardiac ventricle decreased size , abnormal
cardiac ventricle curvature , abnormal
cardiac ventricle cardiac muscle cell shape , abnormal
cardiac ventricle cardiac muscle cell decreased size , abnormal
cardiac ventricle elliptic , abnormal
cardiac ventricle immature , abnormal
cardiac ventricle heart contraction process quality , abnormal
cardiac ventricle increased size , abnormal
cardiac ventricle dilated , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000108 fin fin quality , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000173 bulbus arteriosus bulbus arteriosus increased length , abnormal
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 ZFA:0000471 atrium atrium contractility , abnormal
atrium decreased strength , abnormal
atrium myofibril disorganized , abnormal
atrium malformed , abnormal
atrium decreased contractility , abnormal
atrium non-contractile , abnormal
atrium dilated , abnormal
atrium heart contraction decreased process quality , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal constricted , abnormal
atrioventricular canal decreased amount , abnormal
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 ZFA:0001318 cardiac jelly cardiac jelly distended , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium absent , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005064 atrioventricular valve atrioventricular valve blood circulation process quality , abnormal
atrioventricular valve blood fluid flow rate , abnormal
atrioventricular valve morphology , abnormal
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 ZFA:0005069 sinoatrial node sinoatrial node decreased functionality , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell has fewer parts of type cardiac muscle cell cell projection, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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