ENSMUSG00000053093


Mus musculus

Features
Gene ID: ENSMUSG00000053093
  
Biological name :Myh7
  
Synonyms : Myh7 / Myosin-7 / Q91Z83
  
Possible biological names infered from orthology : myosin heavy chain 7 / P12883
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 54970684
Gene end: 54994626
  
Corresponding Affymetrix probe sets: 10419934 (MoGene1.0st)   1448553_at (Mouse Genome 430 2.0 Array)   1448554_s_at (Mouse Genome 430 2.0 Array)   1448827_s_at (Mouse Genome 430 2.0 Array)   1458850_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154332
Ensembl peptide - ENSMUSP00000154631
Ensembl peptide - ENSMUSP00000154569
Ensembl peptide - ENSMUSP00000099867
Ensembl peptide - ENSMUSP00000116595
Ensembl peptide - ENSMUSP00000126840
NCBI entrez gene - 140781     See in Manteia.
MGI - MGI:2155600
RefSeq - XM_017315841
RefSeq - XM_017315842
RefSeq - NM_080728
RefSeq Peptide - NP_542766
swissprot - Q1WJL6
swissprot - Q91Z83
swissprot - B8JJH1
swissprot - B2RXX9
Ensembl - ENSMUSG00000053093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU633479.1ENSDARG00000098747Danio rerio
 CU633479.2ENSDARG00000103837Danio rerio
 myh6ENSDARG00000090637Danio rerio
 myh7ENSDARG00000079564Danio rerio
 myh7lENSDARG00000079782Danio rerio
 smyhc1ENSDARG00000099959Danio rerio
 smyhc2ENSDARG00000103969Danio rerio
 smyhc2ENSDARG00000114031Danio rerio
 MYH7ENSGALG00000035594Gallus gallus
 MYH7ENSG00000092054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*ENSMUSG0000004075294
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319682
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577582
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632882
Myh4 / Q5SX39 / Myosin-4 / Q9Y623* / myosin heavy chain 4*ENSMUSG0000005700382
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090880
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018078
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465270
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200957
Myh11 / myosin heavy chain 11 / P35749*ENSMUSG0000001883041
Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*ENSMUSG0000002090041
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244341
Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*ENSMUSG0000003073938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction ISO
 biological_processGO:0002027 regulation of heart rate ISO
 biological_processGO:0003009 skeletal muscle contraction ISO
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0014728 regulation of the force of skeletal muscle contraction ISO
 biological_processGO:0014883 transition between fast and slow fiber IDA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:0030049 muscle filament sliding ISO
 biological_processGO:0031449 regulation of slow-twitch skeletal muscle fiber contraction ISO
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISO
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030017 sarcomere ISS
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0032982 myosin filament ISO
 molecular_functionGO:0000146 microfilament motor activity ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0030898 actin-dependent ATPase activity ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Sgon/Bmi1tm1Sgon,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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