ENSDARG00000100657


Danio rerio
egf-likeegfl7sitedomaincalcium-bindingconserveddorsalaortavesselegf-typeaspartateasparaginehydroxylationemivasculogenesiscalciumionbindingbrainposteriorcardinalveinaxialvasculaturewholeorganismintersegmentalventralwallbloodendothelial

Features
Gene ID: ENSDARG00000100657
  
Biological name :egfl7
  
Synonyms : egfl7 / EGF-like-domain, multiple 7
  
Possible biological names infered from orthology : Q9UHF1
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 7228467
Gene end: 7265219
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000140866
NCBI entrez gene - 678640     See in Manteia.
RefSeq - NM_001040385
RefSeq Peptide - NP_001035475
swissprot - Q1RLZ3
ZFIN ID - ZDB-GENE-040429-2
Ensembl - ENSDARG00000100657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGFL7ENSGALG00000043499Gallus gallus
 EGFL7ENSG00000172889Homo sapiens
 Egfl7ENSMUSG00000026921Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
npnt / nephronectin / Q6UXI9* / Q91V88*ENSDARG0000001872123
egfl6 / EGF-like-domain, multiple 6 / Q8IUX8* / Q9JJZ5* / Epidermal growth factor-like protein 6 *ENSDARG0000004595821
si:ch211-194g2.4 / EGFL7* / Q9UHF1* / EGF like domain multiple 7*ENSDARG0000009464815
nephronectin / NPNT (1 of many) / NPNT* / Q6UXI9*ENSDARG0000010079714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR011489  EMI domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
anatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentcellular developmental processanatomical structure developmentanatomical structure developmentcellular developmental processcellular developmental process
ion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion binding
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta obstructed , abnormal
dorsal aorta unlumenized , abnormal
dorsal aorta mislocalised dorsally , abnormal
dorsal aorta blood vessel endothelial cell positional polarity , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein morphology , abnormal
posterior cardinal vein duplicated , abnormal
posterior cardinal vein deformed , abnormal
posterior cardinal vein mislocalised dorsally , abnormal
posterior cardinal vein blood vessel endothelial cell structure , abnormal
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 ZFA:0001073 axial vasculature axial vasculature decreased area , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel morphology , ameliorated
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta deformed , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell mislocalised , abnormal
blood vessel endothelial cell bicellular tight junction increased amount , abnormal
blood vessel endothelial cell bicellular tight junction mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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