ENSDARG00000101560


Danio rerio

Features
Gene ID: ENSDARG00000101560
  
Biological name :psma1
  
Synonyms : proteasome subunit alpha 1 / psma1
  
Possible biological names infered from orthology : AC018523.2 / P25786 / proteasome (prosome, macropain) subunit, alpha type 1 / Q9R1P4
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 37483308
Gene end: 37489917
  
Corresponding Affymetrix probe sets: Dr.9622.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000134179
NCBI entrez gene - 445033     See in Manteia.
swissprot - Q6DGX8
ZFIN ID - ZDB-GENE-040801-15
Ensembl - ENSDARG00000101560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMA1ENSGALG00000006022Gallus gallus
 AC018523.2ENSG00000256206Homo sapiens
 PSMA1ENSG00000129084Homo sapiens
 Psma1ENSMUSG00000030751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000426  Proteasome alpha-subunit, N-terminal domain
 IPR001353  Proteasome, subunit alpha/beta
 IPR023332  Proteasome alpha-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035144  Proteasome subunit alpha 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005839 proteasome core complex IEA
 cellular_componentGO:0019773 proteasome core complex, alpha-subunit complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
FCERI mediated NF-kB activation
The role of GTSE1 in G2/M progression after G2 checkpoint
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of RUNX2 expression and activity
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Degradation of GLI1 by the proteasome
SCF(Skp2)-mediated degradation of p27/p21
Regulation of ornithine decarboxylase (ODC)
Regulation of RAS by GAPs
Asymmetric localization of PCP proteins
Autodegradation of Cdh1 by Cdh1:APC/C
Degradation of beta-catenin by the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
APC/C:Cdc20 mediated degradation of Securin
G2/M Checkpoints
CDT1 association with the CDC6:ORC:origin complex
Dectin-1 mediated noncanonical NF-kB signaling
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Activation of NF-kappaB in B cells
AUF1 (hnRNP D0) binds and destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of AXIN
Degradation of DVL
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
NIK-->noncanonical NF-kB signaling
Orc1 removal from chromatin
Regulation of PTEN stability and activity
Regulation of RUNX3 expression and activity
Separation of Sister Chromatids
TNFR2 non-canonical NF-kB pathway
UCH proteinases
Ub-specific processing proteases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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