ENSDARG00000103409


Danio rerio

Features
Gene ID: ENSDARG00000103409
  
Biological name :uhrf1
  
Synonyms : E7EZF3 / ubiquitin-like with PHD and ring finger domains 1 / uhrf1
  
Possible biological names infered from orthology : Q8VDF2 / Q96T88 / ubiquitin-like, containing PHD and RING finger domains, 1
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 4408643
Gene end: 4439311
  
Corresponding Affymetrix probe sets: Dr.18169.1.S1_at (Zebrafish Array)   Dr.9809.2.S1_at (Zebrafish Array)   NM_213077_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135054
NCBI entrez gene - 406350     See in Manteia.
RefSeq - NM_213077
RefSeq Peptide - NP_998242
swissprot - E7EZF3
ZFIN ID - ZDB-GENE-040426-2039
Ensembl - ENSDARG00000103409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UHRF1ENSGALG00000034271Gallus gallus
 UHRF1ENSG00000276043Homo sapiens
 Uhrf1ENSMUSG00000001228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003105  SRA-YDG
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR021991  UHRF1, tandem tudor domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010390 histone monoubiquitination IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination ISS
 biological_processGO:0031100 animal organ regeneration IMP
 biological_processGO:0044027 hypermethylation of CpG island IMP
 biological_processGO:0051865 protein autoubiquitination ISS
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing IBA
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0000791 euchromatin ISS
 cellular_componentGO:0000792 heterochromatin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005657 replication fork ISS
 cellular_componentGO:0005720 nuclear heterochromatin IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0044729 hemi-methylated DNA-binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens quality , abnormal
lens morphology , abnormal
lens mislocalised , abnormal
lens degenerate , abnormal
lens opaque , abnormal
lens protruding , abnormal
Show

 ZFA:0000084 yolk yolk increased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye morphology , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
gut morphology , abnormal
gut hypoplastic , abnormal
gut decreased size , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver quality , abnormal
liver apoptotic process increased process quality , abnormal
liver cell cycle arrested , abnormal
liver morphology , abnormal
liver regenerating tissue hypoplastic , abnormal
Show

 ZFA:0000217 inner ear inner ear cell death increased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
head cell death increased process quality , abnormal
head decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton cell death increased process quality , abnormal
mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001283 pupil pupil decreased size , abnormal
Show

 ZFA:0001338 intestine intestine has extra parts of type neutrophil , abnormal
intestine neutrophil increased amount , abnormal
Show

 ZFA:0005123 gut epithelium gut epithelium morphology , abnormal
gut epithelium permeability , abnormal
gut epithelium flattened , abnormal
gut epithelium brush border decreased size , abnormal
Show

 ZFA:0005574 lens capsule lens capsule absent , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte nucleus increased size , abnormal
hepatocyte DNA methylation decreased process quality , abnormal
hepatocyte apoptotic , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell morphology , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell morphology , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell cuboid , abnormal
intestinal epithelial cell DNA methylation decreased process quality , abnormal
intestinal epithelial cell apoptotic process increased process quality , abnormal
intestinal epithelial cell decreased height , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr