ENSG00000276043


Homo sapiens

Features
Gene ID: ENSG00000276043
  
Biological name :UHRF1
  
Synonyms : Q96T88 / ubiquitin like with PHD and ring finger domains 1 / UHRF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 4903080
Gene end: 4962154
  
Corresponding Affymetrix probe sets: 225655_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479617
Ensembl peptide - ENSP00000478601
Ensembl peptide - ENSP00000480214
Ensembl peptide - ENSP00000485604
Ensembl peptide - ENSP00000484739
Ensembl peptide - ENSP00000478171
Ensembl peptide - ENSP00000478348
NCBI entrez gene - 29128     See in Manteia.
OMIM - 607990
RefSeq - XM_011527942
RefSeq - NM_001048201
RefSeq - NM_001290050
RefSeq - NM_001290051
RefSeq - NM_001290052
RefSeq - NM_013282
RefSeq Peptide - NP_001276979
RefSeq Peptide - NP_001276980
RefSeq Peptide - NP_001276981
RefSeq Peptide - NP_037414
RefSeq Peptide - NP_001041666
swissprot - A0A087WWG9
swissprot - A0A087WTW0
swissprot - Q96T88
swissprot - A0A087WVR3
Ensembl - ENSG00000276043
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uhrf1ENSDARG00000103409Danio rerio
 UHRF1ENSGALG00000034271Gallus gallus
 Uhrf1ENSMUSG00000001228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UHRF2 / Q96PU4 / ubiquitin like with PHD and ring finger domains 2ENSG0000014785454


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003105  SRA-YDG
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR021991  UHRF1, tandem tudor domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036987  SRA-YDG superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEP
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010390 histone monoubiquitination IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IC
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing IBA
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IC
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0000791 euchromatin IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005720 nuclear heterochromatin IBA
 cellular_componentGO:0016363 nuclear matrix ISS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0008327 methyl-CpG binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031493 nucleosomal histone binding ISS
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0044729 hemi-methylated DNA-binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISS


Pathways (from Reactome)
Pathway description
DNA methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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