ENSDARG00000104348


Danio rerio

Features
Gene ID: ENSDARG00000104348
  
Biological name :fgf2
  
Synonyms : fgf2 / fibroblast growth factor 2
  
Possible biological names infered from orthology : P09038 / P15655
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 567216
Gene end: 572742
  
Corresponding Affymetrix probe sets: DrAffx.1.59.S1_at (Zebrafish Array)   NM_212823_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132803
NCBI entrez gene - 404231     See in Manteia.
RefSeq - NM_212823
RefSeq Peptide - NP_997988
swissprot - A0A0R4IHF9
ZFIN ID - ZDB-GENE-040318-1
Ensembl - ENSDARG00000104348
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF2ENSGALG00000011835Gallus gallus
 FGF2ENSG00000138685Homo sapiens
 Fgf2ENSMUSG00000037225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf1a / fibroblast growth factor 1aENSDARG0000001754238
fgf1b / fibroblast growth factor 1bENSDARG0000004281127


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028223  Fibroblast growth factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0070121 Kupffer"s vesicle development IGI
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle malformed , abnormal
Kupffers vesicle motile cilium decreased amount , abnormal
Show

 ZFA:0000008 brain brain apoptotic , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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