ENSGALG00000011835


Gallus gallus

Features
Gene ID: ENSGALG00000011835
  
Biological name :FGF2
  
Synonyms : FGF2 / Fibroblast growth factor 2 / P48800
  
Possible biological names infered from orthology : P09038 / P15655
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 53933771
Gene end: 53959686
  
Corresponding Affymetrix probe sets: Gga.17040.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000031518
Ensembl peptide - ENSGALP00000031519
NCBI entrez gene - 396413     See in Manteia.
RefSeq - XM_015276159
RefSeq - NM_205433
RefSeq Peptide - NP_990764
swissprot - P48800
swissprot - Q07659
Ensembl - ENSGALG00000011835
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf2ENSDARG00000104348Danio rerio
 FGF2ENSG00000138685Homo sapiens
 Fgf2ENSMUSG00000037225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF1 / P19596 / Fibroblast growth factor 1 Endothelial cell growth factor alpha / P05230* / P61148* / fibroblast growth factor 1*ENSGALG0000003125551


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028223  Fibroblast growth factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001707 mesoderm formation NAS
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001894 tissue homeostasis NAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002089 lens morphogenesis in camera-type eye NAS
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition TAS
 biological_processGO:0003407 neural retina development TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010756 positive regulation of plasminogen activation IMP
 biological_processGO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation ISS
 biological_processGO:0021762 substantia nigra development IEA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0030324 lung development IEA
 biological_processGO:0042060 wound healing NAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISS
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046668 regulation of retinal cell programmed cell death IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048864 stem cell development IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051301 cell division IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060128 corticotropin hormone secreting cell differentiation IEA
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IEA
 biological_processGO:0060563 neuroepithelial cell differentiation IMP
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070660 inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration NAS
 biological_processGO:0072089 stem cell proliferation IMP
 biological_processGO:0072248 metanephric glomerular visceral epithelial cell differentiation NAS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding ISS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014505 FGFBP1 / fibroblast growth factor binding protein 1 / O70514* / Q14512*  / complex / reaction






 

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