ENSGALG00000031255


Gallus gallus

Features
Gene ID: ENSGALG00000031255
  
Biological name :FGF1
  
Synonyms : FGF1 / Fibroblast growth factor 1 Endothelial cell growth factor alpha / P19596
  
Possible biological names infered from orthology : fibroblast growth factor 1 / P05230 / P61148
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 17348659
Gene end: 17363069
  
Corresponding Affymetrix probe sets: Gga.648.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044660
NCBI entrez gene - 396094     See in Manteia.
RefSeq - XM_015294011
RefSeq - NM_205180
RefSeq - XM_015294009
RefSeq - XM_015294010
RefSeq Peptide - NP_990511
swissprot - P19596
Ensembl - ENSGALG00000031255
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF1ENSG00000113578Homo sapiens
 Fgf1ENSMUSG00000036585Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF2 / P48800 / Fibroblast growth factor 2 / P09038* / P15655*ENSGALG0000001183552


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028210  Fibroblast growth factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051781 positive regulation of cell division ISS
 biological_processGO:0060681 branch elongation involved in ureteric bud branching IEA
 biological_processGO:0072163 mesonephric epithelium development IEA
 biological_processGO:1901509 regulation of endothelial tube morphogenesis IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding ISS
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008083 growth factor activity ISS
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0044548 S100 protein binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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