ENSDARG00000105206


Danio rerio

Features
Gene ID: ENSDARG00000105206
  
Biological name :hmgcrb
  
Synonyms : 3-hydroxy-3-methylglutaryl-CoA reductase b / hmgcrb
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 2506013
Gene end: 2533249
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133184
NCBI entrez gene - 541479     See in Manteia.
RefSeq - NM_001014292
RefSeq Peptide - NP_001014314
swissprot - A0A0R4IFH5
ZFIN ID - ZDB-GENE-051108-1
Ensembl - ENSDARG00000105206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hmgcra / 3-hydroxy-3-methylglutaryl-CoA reductase a / HMGCR* / Q01237* / P04035* / 3-hydroxy-3-methylglutaryl-CoA reductase* / 3-hydroxy-3-methylglutaryl-coenzyme A reductase *ENSDARG0000005273472
scap / SREBF chaperone / Q12770* / Q6GQT6*ENSDARG0000001809616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR002202  Hydroxymethylglutaryl-CoA reductase, class I/II
 IPR004554  Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
 IPR004816  Hydroxymethylglutaryl-CoA reductase, metazoan
 IPR009023  Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
 IPR009029  Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
 IPR023074  Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
 IPR023076  Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
 IPR023282  Hydroxymethylglutaryl-CoA reductase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001955 blood vessel maturation IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0015936 coenzyme A metabolic process IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0050662 coenzyme binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
brain ventral region decreased amount , abnormal
Show

 ZFA:0000028 heart primordium heart primordium left side unfused from heart primordium right side, abnormal
Show

 ZFA:0000054 pericardium pericardium nucleate erythrocyte decreased amount , abnormal
pericardium edematous , abnormal
Show

 ZFA:0000056 pharynx pharynx endoderm decreased distribution , abnormal
Show

 ZFA:0000106 extension extension increased thickness , abnormal
Show

 ZFA:0000114 heart heart mislocalised medially , abnormal
heart decreased size , abnormal
Show

 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus mislocalised anteriorly , abnormal
Show

 ZFA:0000561 parasphenoid parasphenoid absent , abnormal
Show

 ZFA:0000694 ceratobranchial 5 tooth ceratobranchial 5 tooth absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001114 head head neural crest cell migration delayed , abnormal
head neural crest cell decreased distribution , abnormal
head neural crest cell decreased amount , abnormal
Show

 ZFA:0001115 trunk trunk neural crest cell migration delayed , abnormal
trunk neural crest cell decreased distribution , abnormal
trunk neural crest cell decreased amount , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium morphology , abnormal
splanchnocranium decreased size , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased length , abnormal
Show

 ZFA:0001319 myocardium myocardium position , abnormal
Show

 ZFA:0001321 neurocranial trabecula neurocranial trabecula decreased size , abnormal
neurocranial trabecula shortened , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage morphology , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage morphology , abnormal
ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage left side increased angle to ceratohyal cartilage right side, abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased length , abnormal
ethmoid cartilage split , abnormal
ethmoid cartilage shortened , abnormal
ethmoid cartilage decreased distribution , abnormal
ethmoid cartilage decreased amount , abnormal
Show

 ZFA:0001425 basal plate cartilage basal plate cartilage absent , abnormal
Show

 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 decreased amount , abnormal
Show

 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 decreased amount , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 decreased amount , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 decreased amount , abnormal
Show

 ZFA:0005463 oral ectoderm oral ectoderm decreased distribution , abnormal
Show

 ZFA:0005509 palate palate shortened , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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