ENSDARG00000052734


Danio rerio

Features
Gene ID: ENSDARG00000052734
  
Biological name :hmgcra
  
Synonyms : 3-hydroxy-3-methylglutaryl-CoA reductase a / hmgcra
  
Possible biological names infered from orthology : 3-hydroxy-3-methylglutaryl-CoA reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase / HMGCR / P04035 / Q01237
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 50972485
Gene end: 50992775
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124862
Ensembl peptide - ENSDARP00000153502
Ensembl peptide - ENSDARP00000088231
NCBI entrez gene - 559054     See in Manteia.
RefSeq - NM_001079977
RefSeq - XM_005165515
RefSeq Peptide - NP_001073446
swissprot - A9JSZ0
ZFIN ID - ZDB-GENE-040401-2
Ensembl - ENSDARG00000052734
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMGCRENSGALG00000014948Gallus gallus
 HMGCRENSG00000113161Homo sapiens
 HmgcrENSMUSG00000021670Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hmgcrb / 3-hydroxy-3-methylglutaryl-CoA reductase bENSDARG0000010520669
scap / SREBF chaperone / Q12770* / Q6GQT6*ENSDARG0000001809617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR002202  Hydroxymethylglutaryl-CoA reductase, class I/II
 IPR004554  Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
 IPR004816  Hydroxymethylglutaryl-CoA reductase, metazoan
 IPR009023  Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
 IPR009029  Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
 IPR023074  Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
 IPR023076  Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
 IPR023282  Hydroxymethylglutaryl-CoA reductase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0008299 isoprenoid biosynthetic process IBA
 biological_processGO:0015936 coenzyme A metabolic process IEA
 biological_processGO:0016126 sterol biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005778 peroxisomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0050662 coenzyme binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001056 myotome myotome skeletal muscle cell morphology , abnormal
Show

 ZFA:0001462 somite border somite border morphology , abnormal
Show

 ZFA:0005145 muscle muscle morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052734 hmgcra / 3-hydroxy-3-methylglutaryl-CoA reductase a / HMGCR* / Q01237* / P04035* / 3-hydroxy-3-methylglutaryl-CoA reductase* / 3-hydroxy-3-methylglutaryl-coenzyme A reductase *  / complex






 

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