ENSGALG00000014948


Gallus gallus

Features
Gene ID: ENSGALG00000014948
  
Biological name :HMGCR
  
Synonyms : 3-hydroxy-3-methylglutaryl-Coenzyme A reductase / HMGCR
  
Possible biological names infered from orthology : 3-hydroxy-3-methylglutaryl-CoA reductase / P04035 / Q01237
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 24008224
Gene end: 24025473
  
Corresponding Affymetrix probe sets: Gga.2785.1.S1_s_at (Chicken Array)   GgaAffx.12414.1.S1_s_at (Chicken Array)   GgaAffx.21726.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024068
NCBI entrez gene - 395145     See in Manteia.
RefSeq - NM_204485
RefSeq - XM_015277226
RefSeq - XM_015277227
RefSeq Peptide - NP_989816
swissprot - E1C420
Ensembl - ENSGALG00000014948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgcraENSDARG00000052734Danio rerio
 HMGCRENSG00000113161Homo sapiens
 HmgcrENSMUSG00000021670Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SCAP / SREBF chaperone / Q12770* / Q6GQT6*ENSGALG000000357689


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR002202  Hydroxymethylglutaryl-CoA reductase, class I/II
 IPR004554  Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
 IPR004816  Hydroxymethylglutaryl-CoA reductase, metazoan
 IPR009023  Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
 IPR009029  Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
 IPR023074  Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
 IPR023076  Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
 IPR023282  Hydroxymethylglutaryl-CoA reductase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process IBA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0015936 coenzyme A metabolic process IEA
 biological_processGO:0016126 sterol biosynthetic process IBA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0042282 hydroxymethylglutaryl-CoA reductase activity IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0050662 coenzyme binding IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014948 HMGCR / 3-hydroxy-3-methylglutaryl-Coenzyme A reductase / P04035* / Q01237* / 3-hydroxy-3-methylglutaryl-CoA reductase*  / complex






 

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