ENSG00000000003


Homo sapiens
signalingTSPAN6regulationmembranereceptorpathwaynf-kappabintegralcomponentecdomainsuperfamilyperipherinconservedsitecellsurfaceviral-inducedcytoplasmicpatternrecognitioni-kappabkinasenikplasmaextracellularexosomeobsoletesignaltransducer

Features
Gene ID: ENSG00000000003
  
Biological name :TSPAN6
  
Synonyms : O43657 / tetraspanin 6 / TSPAN6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.1
Gene start: 100627109
Gene end: 100639991
  
Corresponding Affymetrix probe sets: 209108_at (Human Genome U133 Plus 2.0 Array)   209109_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482130
Ensembl peptide - ENSP00000482894
Ensembl peptide - ENSP00000362111
NCBI entrez gene - 7105     See in Manteia.
OMIM - 300191
RefSeq - XM_011531018
RefSeq - NM_001278740
RefSeq - NM_001278741
RefSeq - NM_001278742
RefSeq - NM_001278743
RefSeq - NM_003270
RefSeq Peptide - NP_001265672
RefSeq Peptide - NP_003261
RefSeq Peptide - NP_001265670
RefSeq Peptide - NP_001265669
RefSeq Peptide - NP_001265671
swissprot - O43657
swissprot - A0A087WZU5
swissprot - A0A087WYV6
Ensembl - ENSG00000000003
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tspan7ENSDARG00000015759Danio rerio
 TSPAN6ENSGALG00000006808Gallus gallus
 Tspan6ENSMUSG00000067377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P41732 / TSPAN7 / tetraspanin 7ENSG0000015629858
AF241726.2ENSG0000025034953
CD151 / P48509 / CD151 molecule (Raph blood group)ENSG0000017769729
O60637 / TSPAN3 / tetraspanin 3ENSG0000014039128
Q96FV3 / TSPAN17 / tetraspanin 17ENSG0000004814027
A1L157 / TSPAN11 / tetraspanin 11ENSG0000011090027
CD63 / P08962 / CD63 moleculeENSG0000013540427
P62079 / TSPAN5 / tetraspanin 5ENSG0000016878527
Q86UF1 / TSPAN33 / tetraspanin 33ENSG0000015845726
Q8NG11 / TSPAN14 / tetraspanin 14ENSG0000010821925
TSPAN10 / tetraspanin 10ENSG0000018261224
O95858 / TSPAN15 / tetraspanin 15ENSG0000009928222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin
 IPR018503  Tetraspanin, conserved site


Gene Ontology (GO)
cell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicationcellular response to stimulusresponse to stressimmune responseresponse to external stimulusresponse to biotic stimuluscytokine productionimmune effector processmulti-organism cellular processcell communicatcell communicationcellular responcellular response to stimulusresponse to strresponse to stressimmune responseimmune responseresponse to extresponse to external stimulusresponse to bioresponse to biotic stimuluscytokine produccytokine productionimmune effectorimmune effector processmulti-organism multi-organism cellular process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellcellmembranemembraneorganelleorganelleextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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