ENSG00000002330


Homo sapiens

Features
Gene ID: ENSG00000002330
  
Biological name :BAD
  
Synonyms : BAD / BCL2 associated agonist of cell death / Q92934
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 64269830
Gene end: 64284704
  
Corresponding Affymetrix probe sets: 1861_at (Human Genome U133 Plus 2.0 Array)   209364_at (Human Genome U133 Plus 2.0 Array)   232660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378040
Ensembl peptide - ENSP00000440575
Ensembl peptide - ENSP00000439202
Ensembl peptide - ENSP00000438975
Ensembl peptide - ENSP00000309103
Ensembl peptide - ENSP00000378039
NCBI entrez gene - 572     See in Manteia.
OMIM - 603167
RefSeq - NM_004322
RefSeq - NM_032989
RefSeq Peptide - NP_004313
RefSeq Peptide - NP_116784
swissprot - A8MXU7
swissprot - Q92934
swissprot - A0A024R562
swissprot - F5GYS3
swissprot - F5H1R6
swissprot - F5H3B1
Ensembl - ENSG00000002330
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 badaENSDARG00000087993Danio rerio
 badbENSDARG00000054937Danio rerio
 BadENSMUSG00000024959Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018868  Bcl2-associated agonist of cell death


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:0006007 glucose catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010508 positive regulation of autophagy TAS
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential ISS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019050 suppression by virus of host apoptotic process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033133 positive regulation of glucokinase activity ISS
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0044342 type B pancreatic cell proliferation ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0045918 negative regulation of cytolysis IMP
 biological_processGO:0046031 ADP metabolic process ISS
 biological_processGO:0046034 ATP metabolic process ISS
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IMP
 biological_processGO:0046931 pore complex assembly IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0060139 positive regulation of apoptotic process by virus IEA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IEA
 biological_processGO:0071247 cellular response to chromate IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071316 cellular response to nicotine IDA
 biological_processGO:0071396 cellular response to lipid IEA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:2000078 positive regulation of type B pancreatic cell development ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IMP
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030346 protein phosphatase 2B binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120910 P48454 / PPP3CC / protein phosphatase 3 catalytic subunit gamma  / reaction
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / reaction
 ENSG00000153094 O43521 / BCL2L11 / BCL2 like 11  / reaction
 ENSG00000171791 BCL2 / P10415 / BCL2, apoptosis regulator  / complex / reaction
 ENSG00000015475 BID / P55957 / BH3 interacting domain death agonist  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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