ENSG00000004948


Homo sapiens

Features
Gene ID: ENSG00000004948
  
Biological name :CALCR
  
Synonyms : calcitonin receptor / CALCR / P30988
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.3
Gene start: 93424487
Gene end: 93574730
  
Corresponding Affymetrix probe sets: 207886_s_at (Human Genome U133 Plus 2.0 Array)   207887_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353385
Ensembl peptide - ENSP00000377959
Ensembl peptide - ENSP00000413179
Ensembl peptide - ENSP00000399552
Ensembl peptide - ENSP00000391369
Ensembl peptide - ENSP00000389295
Ensembl peptide - ENSP00000352561
NCBI entrez gene - 799     See in Manteia.
OMIM - 114131
RefSeq - NM_001742
RefSeq - NM_001164737
RefSeq - NM_001164738
RefSeq Peptide - NP_001158209
RefSeq Peptide - NP_001158210
RefSeq Peptide - NP_001733
swissprot - P30988
swissprot - A0A0C4DG16
swissprot - A0A0A0MSQ7
swissprot - A0A0A0MRG0
swissprot - D8MIV0
Ensembl - ENSG00000004948
  
Related genetic diseases (OMIM): 166710 - {Osteoporosis, postmenopausal, susceptibility}, 166710
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CalcrENSMUSG00000023964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CALCRL / Q16602 / calcitonin receptor like receptorENSG0000006498951
CRHR2 / Q13324 / corticotropin releasing hormone receptor 2ENSG0000010611325
CRHR1 / P34998 / corticotropin releasing hormone receptor 1ENSG0000012008824
LINC02210-CRHR1 / LINC02210-CRHR1 readthroughENSG0000026371515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001688  GPCR, family 2, calcitonin receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003287  GPCR, family 2, calcitonin receptor family
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010739 positive regulation of protein kinase A signaling IGI
 biological_processGO:0010942 positive regulation of cell death IGI
 biological_processGO:0015031 protein transport IDA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IGI
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0051384 response to glucocorticoid IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0097647 amylin receptor signaling pathway IGI
 biological_processGO:1905665 positive regulation of calcium ion import across plasma membrane IGI
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1903440 amylin receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004948 calcitonin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0032841 calcitonin binding IPI
 molecular_functionGO:0097643 amylin receptor activity IGI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122679 RAMP3 / O60896 / receptor activity modifying protein 3  / complex
 ENSG00000131477 RAMP2 / O60895 / receptor activity modifying protein 2  / complex
 ENSG00000121351 IAPP / P10997 / islet amyloid polypeptide  / complex / reaction
 ENSG00000132329 RAMP1 / O60894 / receptor activity modifying protein 1  / complex
 ENSG00000110680 CALCA / P01258 / P06881 / calcitonin related polypeptide alpha  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr