ENSG00000064989


Homo sapiens

Features
Gene ID: ENSG00000064989
  
Biological name :CALCRL
  
Synonyms : calcitonin receptor like receptor / CALCRL / Q16602
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q32.1
Gene start: 187343129
Gene end: 187448460
  
Corresponding Affymetrix probe sets: 206331_at (Human Genome U133 Plus 2.0 Array)   210815_s_at (Human Genome U133 Plus 2.0 Array)   234996_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415626
Ensembl peptide - ENSP00000386599
Ensembl peptide - ENSP00000386972
Ensembl peptide - ENSP00000387190
Ensembl peptide - ENSP00000376177
NCBI entrez gene - 10203     See in Manteia.
OMIM - 114190
RefSeq - XM_017003151
RefSeq - NM_001271751
RefSeq - NM_005795
RefSeq - XM_005246231
RefSeq - XM_005246232
RefSeq - XM_005246234
RefSeq Peptide - NP_001258680
RefSeq Peptide - NP_005786
swissprot - E7EN01
swissprot - Q16602
swissprot - B8ZZJ4
Ensembl - ENSG00000064989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calcrlaENSDARG00000011473Danio rerio
 calcrlbENSDARG00000011571Danio rerio
 CALCRLENSGALG00000002632Gallus gallus
 CalcrlENSMUSG00000059588Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CALCR / P30988 / calcitonin receptorENSG0000000494856
CRHR2 / Q13324 / corticotropin releasing hormone receptor 2ENSG0000010611327
CRHR1 / P34998 / corticotropin releasing hormone receptor 1ENSG0000012008825
LINC02210-CRHR1 / LINC02210-CRHR1 readthroughENSG0000026371516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003287  GPCR, family 2, calcitonin receptor family
 IPR003289  GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IPI
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0015031 protein transport IDA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0071329 cellular response to sucrose stimulus IDA
 biological_processGO:1990408 calcitonin gene-related peptide receptor signaling pathway IPI
 biological_processGO:1990410 adrenomedullin receptor signaling pathway IPI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1903143 adrenomedullin receptor complex IDA
 cellular_componentGO:1990406 CGRP receptor complex IDA
 molecular_functionGO:0001605 adrenomedullin receptor activity IPI
 molecular_functionGO:0001635 calcitonin gene-related peptide receptor activity IPI
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004948 calcitonin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:1990409 adrenomedullin binding IPI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122679 RAMP3 / O60896 / receptor activity modifying protein 3  / complex
 ENSG00000131477 RAMP2 / O60895 / receptor activity modifying protein 2  / complex
 ENSG00000132329 RAMP1 / O60894 / receptor activity modifying protein 1  / complex
 ENSG00000148926 ADM / P35318 / adrenomedullin  / complex / reaction
 ENSG00000175868 CALCB / P10092 / calcitonin related polypeptide beta  / complex / reaction
 ENSG00000110680 CALCA / P01258 / P06881 / calcitonin related polypeptide alpha  / complex / reaction
 ENSG00000128165 ADM2 / Q7Z4H4 / adrenomedullin 2  / complex / reaction






 

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