ENSG00000006638


Homo sapiens
regulationTBXA2Rreceptorresponsethromboxaneactivitymembranegsignalingsignallingrhodopsin-likeprostanoidsignalg-proteincoupledpathwayvasoconstrictionbloodlipopolysaccharideangiogenesisplasmaintegralcomponentalphaeventsprotein-coupledgpcrtminflammatorytransductioncytosolic

Features
Gene ID: ENSG00000006638
  
Biological name :TBXA2R
  
Synonyms : P21731 / TBXA2R / thromboxane A2 receptor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3594506
Gene end: 3606840
  
Corresponding Affymetrix probe sets: 207554_x_at (Human Genome U133 Plus 2.0 Array)   207555_s_at (Human Genome U133 Plus 2.0 Array)   211590_x_at (Human Genome U133 Plus 2.0 Array)   336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364336
Ensembl peptide - ENSP00000393333
Ensembl peptide - ENSP00000468145
NCBI entrez gene - 6915     See in Manteia.
OMIM - 188070
RefSeq - XM_011528214
RefSeq - NM_001060
RefSeq - NM_201636
RefSeq Peptide - NP_001051
RefSeq Peptide - NP_963998
swissprot - P21731
swissprot - K7ER80
Ensembl - ENSG00000006638
  
Related genetic diseases (OMIM): 614009 - {Bleeding disorder, platelet-type, 13, susceptibility to}, 614009
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbxa2rENSDARG00000104717Danio rerio
 TBXA2RENSGALG00000037888Gallus gallus
 P30987ENSMUSG00000034881Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P34995 / PTGER1 / prostaglandin E receptor 1ENSG0000016095131
PTGFR / P43088 / prostaglandin F receptorENSG0000012242030
P43115 / PTGER3 / prostaglandin E receptor 3ENSG0000005062828
PTGIR / P43119 / prostaglandin I2 receptorENSG0000016001324
PTGDR / Q13258 / prostaglandin D2 receptorENSG0000016822922
P43116 / PTGER2 / prostaglandin E receptor 2ENSG0000012538421
P35408 / PTGER4 / prostaglandin E receptor 4ENSG0000017152220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001105  Thromboxane receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
response to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse to stresscell communicationcellular response to stimulusregulation of biological qualityresponse to external stimulusresponse to chemicalsystem processcoagulationresponse to biotic stimulusresponse to endogenous stimulusanatomical structure developmentregulation of molecular functionlocalization of cellmovement of cell or subcellular componenttissue migrationresponse response to stresscell commcell communicationcellular cellular response to stimulusregulatioregulation of biological qualityresponse response to external stimulusresponse response to chemicalsystem prsystem processcoagulaticoagulationresponse response to biotic stimulusresponse response to endogenous stimulusanatomicaanatomical structure developmentregulatioregulation of molecular functionlocalizatlocalization of cellmovement movement of cell or subcellular componenttissue mitissue migration
signaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
cellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellcellorganelleorganellemembranemembranemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019932 second-messenger-mediated signaling IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0038193 thromboxane A2 signaling pathway IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IGI
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004960 thromboxane receptor activity IEA
 molecular_functionGO:0004961 thromboxane A2 receptor activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / complex / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / complex / reaction
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / complex / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction






 

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