ENSG00000171522


Homo sapiens

Features
Gene ID: ENSG00000171522
  
Biological name :PTGER4
  
Synonyms : P35408 / prostaglandin E receptor 4 / PTGER4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p13.1
Gene start: 40679498
Gene end: 40693735
  
Corresponding Affymetrix probe sets: 204896_s_at (Human Genome U133 Plus 2.0 Array)   204897_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302846
NCBI entrez gene - 5734     See in Manteia.
OMIM - 601586
RefSeq - NM_000958
RefSeq Peptide - NP_000949
swissprot - P35408
Ensembl - ENSG00000171522
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptger4aENSDARG00000059236Danio rerio
 ptger4bENSDARG00000035415Danio rerio
 PTGER4ENSGALG00000014824Gallus gallus
 P32240ENSMUSG00000039942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGIR / P43119 / prostaglandin I2 receptorENSG0000016001326
P43116 / PTGER2 / prostaglandin E receptor 2ENSG0000012538423
PTGDR / Q13258 / prostaglandin D2 receptorENSG0000016822923
P34995 / PTGER1 / prostaglandin E receptor 1ENSG0000016095121
P43115 / PTGER3 / prostaglandin E receptor 3ENSG0000005062819
P21731 / TBXA2R / thromboxane A2 receptorENSG0000000663817
PTGFR / P43088 / prostaglandin F receptorENSG0000012242017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001244  Prostaglandin DP receptor
 IPR001758  Prostanoid EP4 receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007254 JNK cascade ISS
 biological_processGO:0009612 response to mechanical stimulus IEP
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033624 negative regulation of integrin activation IDA
 biological_processGO:0042093 T-helper cell differentiation IEA
 biological_processGO:0050710 negative regulation of cytokine secretion IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0060348 bone development ISS
 biological_processGO:0070371 ERK1 and ERK2 cascade ISS
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IBA
 biological_processGO:2000420 negative regulation of eosinophil extravasation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004955 prostaglandin receptor activity IEA
 molecular_functionGO:0004957 prostaglandin E receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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