ENSG00000010310


Homo sapiens

Features
Gene ID: ENSG00000010310
  
Biological name :GIPR
  
Synonyms : gastric inhibitory polypeptide receptor / GIPR / P48546
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45668244
Gene end: 45683724
  
Corresponding Affymetrix probe sets: 208105_at (Human Genome U133 Plus 2.0 Array)   231291_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305321
Ensembl peptide - ENSP00000467342
Ensembl peptide - ENSP00000467494
Ensembl peptide - ENSP00000263281
Ensembl peptide - ENSP00000465385
NCBI entrez gene - 2696     See in Manteia.
OMIM - 137241
RefSeq - XM_011526716
RefSeq - XM_011526710
RefSeq - XM_011526711
RefSeq - XM_011526713
RefSeq - XM_011526714
RefSeq - XM_011526715
RefSeq - NM_000164
RefSeq - NM_001308418
RefSeq - XM_011526709
RefSeq Peptide - NP_000155
RefSeq Peptide - NP_001295347
swissprot - K7EPD9
swissprot - P48546
swissprot - K7EJZ3
Ensembl - ENSG00000010310
  
Related genetic diseases (OMIM): 137241 - [Plasma glucose, 2-hour, QTL 2]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 giprENSDARG00000025478Danio rerio
 GiprENSMUSG00000030406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GCGR / P47871 / glucagon receptorENSG0000021564449
GLP1R / P43220 / glucagon like peptide 1 receptorENSG0000011216441
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532539
SCTR / P47872 / secretin receptorENSG0000008029335
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080135
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481234
P41586 / ADCYAP1R1 / ADCYAP receptor type IENSG0000007854932
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601832
PTH2R / P49190 / parathyroid hormone 2 receptorENSG0000014440730
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001749  GPCR, family 2, gastric inhibitory polypeptide receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient TAS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0038192 gastric inhibitory peptide signaling pathway IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016519 gastric inhibitory peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000159224 GIP / P09681 / gastric inhibitory polypeptide  / complex / reaction






 

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