ENSG00000215644


Homo sapiens

Features
Gene ID: ENSG00000215644
  
Biological name :GCGR
  
Synonyms : GCGR / glucagon receptor / P47871
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 81804132
Gene end: 81814013
  
Corresponding Affymetrix probe sets: 210565_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383558
Ensembl peptide - ENSP00000458930
Ensembl peptide - ENSP00000460976
NCBI entrez gene - 2642     See in Manteia.
OMIM - 138033
RefSeq - XM_017024447
RefSeq - NM_000160
RefSeq - XM_006722277
RefSeq - XM_011523539
RefSeq - XM_017024446
RefSeq Peptide - NP_000151
swissprot - I3L454
swissprot - I3L1L8
swissprot - P47871
Ensembl - ENSG00000215644
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcgraENSDARG00000104022Danio rerio
 gcgrbENSDARG00000036272Danio rerio
 GCGRENSGALG00000011219Gallus gallus
 GcgrENSMUSG00000025127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GIPR / P48546 / gastric inhibitory polypeptide receptorENSG0000001031048
GLP1R / P43220 / glucagon like peptide 1 receptorENSG0000011216445
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532541
SCTR / P47872 / secretin receptorENSG0000008029335
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481234
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601832
P41586 / ADCYAP1R1 / ADCYAP receptor type IENSG0000007854931
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080131
PTH2R / P49190 / parathyroid hormone 2 receptorENSG0000014440730
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003290  GPCR, family 2, glucagon-like peptide-1/glucagon receptor
 IPR003291  GPCR, family 2, glucagon receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007584 response to nutrient TAS
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070873 regulation of glycogen metabolic process IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004967 glucagon receptor activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001081 Cholelithiasis 
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 HP:0002027 Abdominal pain 
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 HP:0002894 Pancreatic cancer 
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 HP:0012440 Abnormal biliary tract morphology "A structural abnormality of the `biliary tree` (FMA:14665)." [HPO:probinson]
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 HP:0030404 Glucagonoma "An endocrine tumor of the pancreas that secretes excessive amounts of glucagon." [HPO:probinson]
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 HP:0030688 Increased glucagon level "An elevated concentration of glucagon in the blood circulation." []
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115263 GCG / P01275 / glucagon  / complex / reaction
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / reaction
 ENSG00000114450 GNB4 / Q9HAV0 / G protein subunit beta 4  / reaction
 ENSG00000087460 GNAS / O95467 / Q5JWF2 / P63092 / P84996 / GNAS complex locus  / reaction
 ENSG00000172354 GNB2 / P62879 / G protein subunit beta 2  / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction






 

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