ENSG00000074800


Homo sapiens

Features
Gene ID: ENSG00000074800
  
Biological name :ENO1
  
Synonyms : ENO1 / enolase 1 / P06733
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.23
Gene start: 8861000
Gene end: 8879250
  
Corresponding Affymetrix probe sets: 201231_s_at (Human Genome U133 Plus 2.0 Array)   216554_s_at (Human Genome U133 Plus 2.0 Array)   217294_s_at (Human Genome U133 Plus 2.0 Array)   240258_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495805
Ensembl peptide - ENSP00000495946
Ensembl peptide - ENSP00000496562
Ensembl peptide - ENSP00000234590
Ensembl peptide - ENSP00000466406
Ensembl peptide - ENSP00000468392
Ensembl peptide - ENSP00000493526
Ensembl peptide - ENSP00000494470
Ensembl peptide - ENSP00000495530
Ensembl peptide - ENSP00000495568
Ensembl peptide - ENSP00000495581
NCBI entrez gene - 2023     See in Manteia.
OMIM - 172430
RefSeq - XM_006710433
RefSeq - NM_001201483
RefSeq - NM_001353346
RefSeq - NM_001428
RefSeq Peptide - NP_001340275
RefSeq Peptide - NP_001188412
RefSeq Peptide - NP_001419
swissprot - P06733
swissprot - K7EM90
swissprot - A0A024R4F1
swissprot - K7ERS8
Ensembl - ENSG00000074800
  
Related genetic diseases (OMIM): 172430 - Enolase deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eno1aENSDARG00000022456Danio rerio
 eno1bENSDARG00000013750Danio rerio
 Eno1ENSMUSG00000063524Mus musculus
 Eno1bENSMUSG00000059040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENO3 / P13929 / enolase 3ENSG0000010851583
ENO2 / P09104 / enolase 2ENSG0000011167483
ENO4 / A6NNW6 / enolase family member 4ENSG0000018831627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000941  Enolase
 IPR020809  Enolase, conserved site
 IPR020810  Enolase, C-terminal TIM barrel domain
 IPR020811  Enolase, N-terminal
 IPR029017  Enolase-like, N-terminal
 IPR034390  Enolase-like superfamily
 IPR036849  Enolase-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0010756 positive regulation of plasminogen activation IMP
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045933 positive regulation of muscle contraction IGI
 biological_processGO:0061621 canonical glycolysis IMP
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IGI
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IGI
 cellular_componentGO:0000015 phosphopyruvate hydratase complex IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004634 phosphopyruvate hydratase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Glycolysis
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000074800 ENO1 / P06733 / enolase 1  / complex






 

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