ENSG00000078687


Homo sapiens

Features
Gene ID: ENSG00000078687
  
Biological name :TNRC6C
  
Synonyms : Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 77959240
Gene end: 78108835
  
Corresponding Affymetrix probe sets: 1561041_at (Human Genome U133 Plus 2.0 Array)   222820_at (Human Genome U133 Plus 2.0 Array)   227149_at (Human Genome U133 Plus 2.0 Array)   228591_at (Human Genome U133 Plus 2.0 Array)   242314_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468647
Ensembl peptide - ENSP00000467154
Ensembl peptide - ENSP00000489933
Ensembl peptide - ENSP00000301624
Ensembl peptide - ENSP00000336783
Ensembl peptide - ENSP00000465707
Ensembl peptide - ENSP00000466277
NCBI entrez gene - 57690     See in Manteia.
OMIM - 610741
RefSeq - XM_017024908
RefSeq - XM_006721996
RefSeq - XM_006721997
RefSeq - XM_006722000
RefSeq - XM_011525088
RefSeq - XM_017024906
RefSeq - XM_017024907
RefSeq - NM_001142640
RefSeq - NM_018996
RefSeq Peptide - NP_001136112
RefSeq Peptide - NP_061869
swissprot - K7EKN9
swissprot - K7ELY5
swissprot - Q9HCJ0
swissprot - A0A1B0GU24
Ensembl - ENSG00000078687
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrc6c1ENSDARG00000076847Danio rerio
 tnrc6c2ENSDARG00000103851Danio rerio
 TNRC6CENSGALG00000001725Gallus gallus
 Tnrc6cENSMUSG00000025571Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NDV7 / TNRC6A / trinucleotide repeat containing 6AENSG0000009090544
Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6BENSG0000010035436


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR019486  Argonaute hook domain
 IPR026805  GW182, middle domain
 IPR032226  TNRC6, PABC binding domain
 IPR033499  Trinucleotide repeat-containing gene 6C protein
 IPR034927  TNRC6C, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035195 gene silencing by miRNA IGI
 biological_processGO:0035278 miRNA mediated inhibition of translation TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Post-transcriptional silencing by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex / reaction
 ENSG00000126070 AGO3 / Q9H9G7 / argonaute 3, RISC catalytic component  / complex
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex
 ENSG00000134698 AGO4 / Q9HCK5 / argonaute 4, RISC catalytic component  / complex






 

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