ENSG00000100029


Homo sapiens
rrnaPES1lsu-rrnasnucleolusbindingbrctdomainmaturationtricistronictranscriptssu-rrnaprocessingcellproteinbiogenesislargesubunitchromosomecytosolcomplexpescadillosuperfamilyorganizationproliferationlocalizationorganelleribosomeribosomalregulationcycle

Features
Gene ID: ENSG00000100029
  
Biological name :PES1
  
Synonyms : O00541 / PES1 / pescadillo ribosomal biogenesis factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.2
Gene start: 30576625
Gene end: 30607083
  
Corresponding Affymetrix probe sets: 202212_at (Human Genome U133 Plus 2.0 Array)   236434_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384366
Ensembl peptide - ENSP00000384252
Ensembl peptide - ENSP00000384777
Ensembl peptide - ENSP00000404234
Ensembl peptide - ENSP00000385654
Ensembl peptide - ENSP00000334612
Ensembl peptide - ENSP00000346725
NCBI entrez gene - 23481     See in Manteia.
OMIM - 605819
RefSeq - XM_017028678
RefSeq - NM_001243225
RefSeq - NM_001282327
RefSeq - NM_001282328
RefSeq - NM_014303
RefSeq - XM_006724173
RefSeq Peptide - NP_055118
RefSeq Peptide - NP_001230154
RefSeq Peptide - NP_001269256
RefSeq Peptide - NP_001269257
swissprot - H7C267
swissprot - B5MCF9
swissprot - B3KXD6
swissprot - O00541
swissprot - B2RDF2
swissprot - H7BYY8
Ensembl - ENSG00000100029
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pesENSDARG00000018902Danio rerio
 PES1ENSGALG00000007778Gallus gallus
 Pes1ENSMUSG00000020430Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR010613  Pescadillo
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationmacromolecule localizationcellular localizationcell cyclenitrogen compounitrogen compound metabolic processcellular componcellular component biogenesiscellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcellular componcellular component organizationmacromolecule lmacromolecule localizationcellular localicellular localizationcell cyclecell cycle
organic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein bindingprotein-containing complex bindingprotein-containing complex binding
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
 biological_processGO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0007000 nucleolus organization IEA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0033365 protein localization to organelle IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IC
 biological_processGO:0051726 regulation of cell cycle IMP
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030687 preribosome, large subunit precursor IDA
 cellular_componentGO:0070545 PeBoW complex IDA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117395 Q99848 / EBNA1BP2 / EBNA1 binding protein 2  / complex
 ENSG00000138442 WDR12 / Q9GZL7 / WD repeat domain 12  / complex
 ENSG00000165732 DDX21 / Q9NR30 / DExD-box helicase 21  / complex
 ENSG00000163938 GNL3 / Q9BVP2 / G protein nucleolar 3  / complex
 ENSG00000261236 BOP1 / Q14137 / block of proliferation 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr