ENSG00000100197


Homo sapiens

Features
Gene ID: ENSG00000100197
  
Biological name :CYP2D6
  
Synonyms : CYP2D6 / cytochrome P450 family 2 subfamily D member 6 / P10635
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.2
Gene start: 42126499
Gene end: 42130906
  
Corresponding Affymetrix probe sets: 207498_s_at (Human Genome U133 Plus 2.0 Array)   215809_at (Human Genome U133 Plus 2.0 Array)   217468_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351927
Ensembl peptide - ENSP00000353241
Ensembl peptide - ENSP00000353820
Ensembl peptide - ENSP00000496296
Ensembl peptide - ENSP00000496150
Ensembl peptide - ENSP00000374620
NCBI entrez gene - 107987478     See in Manteia.
NCBI entrez gene - 107987479     See in Manteia.
NCBI entrez gene - 1565     See in Manteia.
OMIM - 124030
RefSeq - XM_011529972
RefSeq - NM_001025161
RefSeq - XM_011529966
RefSeq - XM_011529968
RefSeq - XM_011529970
RefSeq - NM_000106
swissprot - C1ID52
swissprot - H7BY38
swissprot - P10635
swissprot - E7ENE7
Ensembl - ENSG00000100197
  
Related genetic diseases (OMIM): 608902 - {Codeine sensitivity}, 608902
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2D6ENSGALG00000011894Gallus gallus
 Cyp2d12ENSMUSG00000096852Mus musculus
 Cyp2d22ENSMUSG00000061740Mus musculus
 Cyp2d26ENSMUSG00000022445Mus musculus
 Cyp2d34ENSMUSG00000094559Mus musculus
 Cyp2d40ENSMUSG00000068083Mus musculus
 Cyp2d9ENSMUSG00000068086Mus musculus
 P24456ENSMUSG00000094806Mus musculus
 P24457ENSMUSG00000068085Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP2D7 / A0A087X1C5 / cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)ENSG0000020570294
CYP2J2 / P51589 / cytochrome P450 family 2 subfamily J member 2ENSG0000013471642
CYP2U1 / Q7Z449 / cytochrome P450 family 2 subfamily U member 1ENSG0000015501641
CYP2W1 / Q8TAV3 / cytochrome P450 family 2 subfamily W member 1ENSG0000007306740
CYP2R1 / Q6VVX0 / cytochrome P450 family 2 subfamily R member 1ENSG0000018610439


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008069  Cytochrome P450, E-class, group I, CYP2D-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0009804 coumarin metabolic process IDA
 biological_processGO:0009820 alkaloid metabolic process IDA
 biological_processGO:0009822 alkaloid catabolic process IDA
 biological_processGO:0016098 monoterpenoid metabolic process IDA
 biological_processGO:0017144 drug metabolic process IMP
 biological_processGO:0019369 arachidonic acid metabolic process IBA
 biological_processGO:0033076 isoquinoline alkaloid metabolic process IDA
 biological_processGO:0042737 drug catabolic process IDA
 biological_processGO:0046483 heterocycle metabolic process IDA
 biological_processGO:0051100 negative regulation of binding IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070989 oxidative demethylation IDA
 biological_processGO:0090350 negative regulation of cellular organofluorine metabolic process IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Miscellaneous substrates
Xenobiotics
CYP2E1 reactions
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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