ENSG00000100949


Homo sapiens

Features
Gene ID: ENSG00000100949
  
Biological name :RABGGTA
  
Synonyms : Q92696 / Rab geranylgeranyltransferase alpha subunit / RABGGTA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24265538
Gene end: 24271739
  
Corresponding Affymetrix probe sets: 203573_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452890
Ensembl peptide - ENSP00000453207
Ensembl peptide - ENSP00000453596
Ensembl peptide - ENSP00000453890
Ensembl peptide - ENSP00000216840
Ensembl peptide - ENSP00000382341
Ensembl peptide - ENSP00000453001
Ensembl peptide - ENSP00000453201
NCBI entrez gene - 5875     See in Manteia.
OMIM - 601905
RefSeq - NM_004581
RefSeq - NM_182836
RefSeq Peptide - NP_004572
RefSeq Peptide - NP_878256
swissprot - Q92696
swissprot - H0YKP6
swissprot - H0YKZ8
swissprot - H0YLG7
swissprot - H0YLH3
swissprot - H0YMG5
Ensembl - ENSG00000100949
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabggtaENSDARG00000061024Danio rerio
 Q9JHK4ENSMUSG00000040472Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR002088  Protein prenyltransferase, alpha subunit
 IPR009087  Rab geranylgeranyltransferase, alpha subunit, insert-domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032955  Geranylgeranyl transferase type-2 subunit alpha
 IPR036254  Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0018342 protein prenylation IEA
 biological_processGO:0018344 protein geranylgeranylation IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0065003 protein-containing complex assembly IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005968 Rab-protein geranylgeranyltransferase complex IEA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004663 Rab geranylgeranyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008318 protein prenyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex / reaction
 ENSG00000137955 P53611 / RABGGTB / Rab geranylgeranyltransferase beta subunit  / complex / reaction






 

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