ENSG00000101280


Homo sapiens
regulationANGPT4fibrinogenc-terminalmigrationalphabetagammachainglobularangiogenesisreceptortyrosinekinaseendothelialcellsubdomaintransmembraneproteinactivitysignalingbloodvesselextracellulardomainconservedsiteangiopoietin-fibrinogen-likeactivationnotch

Features
Gene ID: ENSG00000101280
  
Biological name :ANGPT4
  
Synonyms : angiopoietin 4 / ANGPT4 / Q9Y264
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p13
Gene start: 869899
Gene end: 916317
  
Corresponding Affymetrix probe sets: 221134_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371347
NCBI entrez gene - 51378     See in Manteia.
OMIM - 603705
RefSeq - XM_011529239
RefSeq - NM_001322809
RefSeq - NM_015985
RefSeq Peptide - NP_057069
RefSeq Peptide - NP_001309738
swissprot - Q9Y264
Ensembl - ENSG00000101280
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt4ENSDARG00000076787Danio rerio
 ANGPT4ENSGALG00000040755Gallus gallus
 Angpt4ENSMUSG00000027460Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANGPT1 / Q15389 / angiopoietin 1ENSG0000015418845
ANGPT2 / O15123 / angiopoietin 2ENSG0000009187944
Q8NI99 / ANGPTL6 / angiopoietin like 6ENSG0000013081226
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685925
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181925
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619424
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795123
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072022
FCN1 / O00602 / ficolin 1ENSG0000008526519
FCN2 / Q15485 / ficolin 2ENSG0000016033919
MFAP4 / P55083 / microfibril associated protein 4ENSG0000016648218
FCN3 / O75636 / ficolin 3ENSG0000014274817


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028845  Angiopoietin-4
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
anatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomical structure developmentnitrogen compound metabolic processcell communicationcellular component organizationcellular component biogenesiscellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationcell deathresponse to stressresponse to chemicalresponse to abiotic stimulusanatomicanatomical structure developmentnitrogennitrogen compound metabolic processcell comcell communicationcellularcellular component organizationcellularcellular component biogenesiscellularcellular metabolic processprimary primary metabolic processregulatiregulation of molecular functionorganic organic substance metabolic processcellularcellular response to stimuluslocalizalocalization of cellmovementmovement of cell or subcellular componenttissue mtissue migrationcell deacell deathresponseresponse to stressresponseresponse to chemicalresponseresponse to abiotic stimulus
receptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityenzyme regulator activityprotein bindingreceptor regulator activityreceptor regulator activityenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0071456 cellular response to hypoxia IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IDA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IDA


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction






 

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