ENSG00000106459


Homo sapiens

Features
Gene ID: ENSG00000106459
  
Biological name :NRF1
  
Synonyms : NRF1 / nuclear respiratory factor 1 / Q16656
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q32.2
Gene start: 129611714
Gene end: 129757082
  
Corresponding Affymetrix probe sets: 204651_at (Human Genome U133 Plus 2.0 Array)   204652_s_at (Human Genome U133 Plus 2.0 Array)   211279_at (Human Genome U133 Plus 2.0 Array)   211280_s_at (Human Genome U133 Plus 2.0 Array)   243189_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309826
Ensembl peptide - ENSP00000394877
Ensembl peptide - ENSP00000376924
Ensembl peptide - ENSP00000376922
Ensembl peptide - ENSP00000342351
Ensembl peptide - ENSP00000223190
NCBI entrez gene - 4899     See in Manteia.
OMIM - 600879
RefSeq - NM_001293163
RefSeq - NM_001293164
RefSeq - NM_005011
RefSeq - NM_001040110
RefSeq Peptide - NP_001035199
RefSeq Peptide - NP_001280093
RefSeq Peptide - NP_005002
RefSeq Peptide - NP_001280092
swissprot - Q16656
swissprot - A0A024R774
swissprot - A0A024R770
swissprot - C9JP85
Ensembl - ENSG00000106459
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrf1ENSDARG00000000018Danio rerio
 NRF1ENSGALG00000040060Gallus gallus
 Nrf1ENSMUSG00000058440Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019525  Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
 IPR019526  Nuclear respiratory factor-1, activation binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155846 Q86YN6 / PPARGC1B / PPARG coactivator 1 beta  / complex / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / complex / reaction
 ENSG00000148840 PPRC1 / Q5VV67 / peroxisome proliferator-activated receptor gamma, coactivator-related 1  / complex / reaction






 

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