ENSG00000106803


Homo sapiens

Features
Gene ID: ENSG00000106803
  
Biological name :SEC61B
  
Synonyms : P60468 / SEC61B / Sec61 translocon beta subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.33
Gene start: 99222064
Gene end: 99230615
  
Corresponding Affymetrix probe sets: 203133_at (Human Genome U133 Plus 2.0 Array)   244700_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000223641
Ensembl peptide - ENSP00000474122
NCBI entrez gene - 10952     See in Manteia.
OMIM - 609214
RefSeq - NM_006808
RefSeq Peptide - NP_006799
swissprot - P60468
swissprot - S4R3B5
Ensembl - ENSG00000106803
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec61bENSDARG00000076568Danio rerio
 SEC61BENSGALG00000013569Gallus gallus
 Gm10320ENSMUSG00000092116Mus musculus
 Q9CQS8ENSMUSG00000053317Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016482  Protein transport protein SecG/Sec61-beta/Sbh
 IPR030671  Protein transport Sec61-beta/Sbh


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IMP
 biological_processGO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IBA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IDA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IMP
 biological_processGO:0031204 posttranslational protein targeting to membrane, translocation IBA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005784 Sec61 translocon complex IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0031205 endoplasmic reticulum Sec complex IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IBA
 molecular_functionGO:0048408 epidermal growth factor binding IPI


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
SRP-dependent cotranslational protein targeting to membrane
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000058262 P61619 / SEC61A1 / Sec61 translocon alpha 1 subunit  / complex
 ENSG00000065665 Q9H9S3 / SEC61A2 / Sec61 translocon alpha 2 subunit  / complex
 ENSG00000008952 SEC62 / Q99442 / SEC62 homolog, preprotein translocation factor  / complex
 ENSG00000132432 P60059 / SEC61G / Sec61 translocon gamma subunit  / complex
 ENSG00000025796 SEC63 / Q9UGP8 / SEC63 homolog, protein translocation regulator  / complex
 ENSG00000198356 ASNA1 / O43681 / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)  / reaction






 

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