ENSG00000107130


Homo sapiens
bindingNCS1ionef-handcalciummembranedomainregulationcytoplasmpostsynapticproteinpaircalcium-bindingsiteneuronprojectiondevelopmentexocytosisphosphatidylinositol-mediatedsignalingtransmembranetransportgolgiapparatuscytosolplasmadensitycelljunctionaxondendrite

Features
Gene ID: ENSG00000107130
  
Biological name :NCS1
  
Synonyms : NCS1 / neuronal calcium sensor 1 / P62166
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.11
Gene start: 130172578
Gene end: 130237304
  
Corresponding Affymetrix probe sets: 218266_s_at (Human Genome U133 Plus 2.0 Array)   222570_at (Human Genome U133 Plus 2.0 Array)   230138_at (Human Genome U133 Plus 2.0 Array)   230146_s_at (Human Genome U133 Plus 2.0 Array)   238753_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486695
Ensembl peptide - ENSP00000361475
NCBI entrez gene - 23413     See in Manteia.
OMIM - 603315
RefSeq - NM_001128826
RefSeq - NM_014286
RefSeq Peptide - NP_001122298
RefSeq Peptide - NP_055101
swissprot - P62166
swissprot - A0A024R8B2
Ensembl - ENSG00000107130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncs1aENSDARG00000055229Danio rerio
 ncs1bENSDARG00000054186Danio rerio
 NCS1ENSGALG00000012710Gallus gallus
 Ncs1ENSMUSG00000062661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCALD / P61601 / neurocalcin deltaENSG0000010449059
HPCAL1 / P37235 / hippocalcin like 1ENSG0000011575659
HPCA / P84074 / hippocalcinENSG0000012190558
VSNL1 / P62760 / visinin like 1ENSG0000016303257
HPCAL4 / Q9UM19 / hippocalcin like 4ENSG0000011698356
RCVRN / P35243 / recoverinENSG0000010904745
KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1ENSG0000018213245
KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3ENSG0000011504144
KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2ENSG0000012004944
KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4ENSG0000018577444
GUCA1B / Q9UMX6 / guanylate cyclase activator 1BENSG0000011259938
GUCA1A / P43080 / guanylate cyclase activator 1AENSG0000004854535
GUCA1C / O95843 / guanylate cyclase activator 1CENSG0000013847229


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
cellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component organizationanatomical structure developmentcellular developmental processestablishment of localizationcell communicationcellular response to stimuluscellular component orgacellular component organizationanatomical structure deanatomical structure developmentcellular developmental cellular developmental processestablishment of localiestablishment of localizationcell communicationcell communicationcellular response to stcellular response to stimulus
ion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingtransmembrane transporter activityprotein bindingion bindingion bindingtransmembrane transporter activitytransmembrane transporter activityprotein bindingprotein binding
cellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellorganellemembranesynapsecell junctionextracellular regioncellcellorganelleorganellemembranemembranesynapsesynapsecell junctioncell junctionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0010975 regulation of neuron projection development ISS
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity ISS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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