ENSG00000107954


Homo sapiens

Features
Gene ID: ENSG00000107954
  
Biological name :NEURL1
  
Synonyms : neuralized E3 ubiquitin protein ligase 1 / NEURL1 / O76050
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.33
Gene start: 103493979
Gene end: 103592552
  
Corresponding Affymetrix probe sets: 204888_s_at (Human Genome U133 Plus 2.0 Array)   204889_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358795
Ensembl peptide - ENSP00000387714
Ensembl peptide - ENSP00000416709
NCBI entrez gene - 9148     See in Manteia.
OMIM - 603804
RefSeq - XM_017016909
RefSeq - NM_004210
RefSeq - XM_005270270
RefSeq - XM_011540331
RefSeq - XM_011540332
RefSeq - XM_011540333
RefSeq - XM_005270269
RefSeq Peptide - NP_004201
swissprot - O76050
swissprot - X6RBV8
swissprot - X6RLA8
Ensembl - ENSG00000107954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurl1aaENSDARG00000069438Danio rerio
 NEURL1ENSGALG00000008281Gallus gallus
 Q923S6ENSMUSG00000006435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A8MQ27 / NEURL1B / neuralized E3 ubiquitin protein ligase 1BENSG0000021435740
NEURL3 / Q96EH8 / neuralized E3 ubiquitin protein ligase 3ENSG0000016312115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR006573  Neuralized homology repeat (NHR) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007288 sperm axoneme assembly IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IDA
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0090129 positive regulation of synapse maturation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097440 apical dendrite IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045183 translation factor activity, non-nucleic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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