ENSMUSG00000006435


Mus musculus

Features
Gene ID: ENSMUSG00000006435
  
Biological name :Neurl1a
  
Synonyms : E3 ubiquitin-protein ligase NEURL1 / Neurl1a / Q923S6
  
Possible biological names infered from orthology : neuralized E3 ubiquitin protein ligase 1 / NEURL1 / O76050
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 47178820
Gene end: 47259440
  
Corresponding Affymetrix probe sets: 10463789 (MoGene1.0st)   1451872_a_at (Mouse Genome 430 2.0 Array)   1453527_a_at (Mouse Genome 430 2.0 Array)   1456854_at (Mouse Genome 430 2.0 Array)   1458561_at (Mouse Genome 430 2.0 Array)   1460343_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107438
Ensembl peptide - ENSMUSP00000107439
NCBI entrez gene - 18011     See in Manteia.
MGI - MGI:1334263
RefSeq - NM_001163480
RefSeq - NM_021360
RefSeq Peptide - NP_001156952
RefSeq Peptide - NP_067335
swissprot - Q923S6
Ensembl - ENSMUSG00000006435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurl1aaENSDARG00000069438Danio rerio
 NEURL1ENSGALG00000008281Gallus gallus
 NEURL1ENSG00000107954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q0MW30 / Neurl1b / E3 ubiquitin-protein ligase NEURL1B / A8MQ27* / neuralized E3 ubiquitin protein ligase 1B*ENSMUSG0000003441337
Neurl3 / Q8CJC5 / E3 ubiquitin-protein ligase NEURL3 / Q96EH8* / neuralized E3 ubiquitin protein ligase 3*ENSMUSG0000004718015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR006573  Neuralized homology repeat (NHR) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway ISS
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity IDA
 biological_processGO:0051491 positive regulation of filopodium assembly IDA
 biological_processGO:0060999 positive regulation of dendritic spine development IDA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0090129 positive regulation of synapse maturation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097440 apical dendrite IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045183 translation factor activity, non-nucleic acid binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009830 abnormal sperm connecting piece morphology "any structural abnormality in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum" [PMID:14581499]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009839 multiflagellated sperm "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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