ENSG00000108774


Homo sapiens

Features
Gene ID: ENSG00000108774
  
Biological name :RAB5C
  
Synonyms : P51148 / RAB5C / RAB5C, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 42124976
Gene end: 42155044
  
Corresponding Affymetrix probe sets: 201140_s_at (Human Genome U133 Plus 2.0 Array)   201156_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449777
Ensembl peptide - ENSP00000449612
Ensembl peptide - ENSP00000467144
Ensembl peptide - ENSP00000345689
Ensembl peptide - ENSP00000377440
Ensembl peptide - ENSP00000447053
Ensembl peptide - ENSP00000448314
NCBI entrez gene - 5878     See in Manteia.
OMIM - 604037
RefSeq - XM_011525091
RefSeq - NM_001252039
RefSeq - NM_004583
RefSeq - NM_201434
RefSeq - XM_011525090
RefSeq Peptide - NP_958842
RefSeq Peptide - NP_001238968
RefSeq Peptide - NP_004574
swissprot - F8VWU4
swissprot - K7ENY4
swissprot - F8VSF8
swissprot - F8VVK3
swissprot - P51148
swissprot - A0A024R1U4
Ensembl - ENSG00000108774
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab5cENSDARG00000026712Danio rerio
 RAB5CENSGALG00000003359Gallus gallus
 Rab5cENSMUSG00000019173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB5A / P20339 / RAB5A, member RAS oncogene familyENSG0000014456676
RAB5B / P61020 / RAB5B, member RAS oncogene familyENSG0000011154073
AC099811.2ENSG0000026726163
Q9UL26 / RAB22A / RAB22A, member RAS oncogene familyENSG0000012420939
RAB17 / Q9H0T7 / RAB17, member RAS oncogene familyENSG0000012483937
RAB31 / Q13636 / RAB31, member RAS oncogene familyENSG0000016846137
RAB21 / Q9UL25 / RAB21, member RAS oncogene familyENSG0000008037134
RAB20 / Q9NX57 / RAB20, member RAS oncogene familyENSG0000013983227
Q9NZQ0 / DNAJC27 / DnaJ heat shock protein family (Hsp40) member C27ENSG0000011513723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048227 plasma membrane to endosome transport IMP
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IBA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000103365 GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2  / complex
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex
 ENSG00000100083 GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1  / complex
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / complex / reaction






 

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