ENSDARG00000026712


Danio rerio

Features
Gene ID: ENSDARG00000026712
  
Biological name :rab5c
  
Synonyms : rab5c / RAB5C, member RAS oncogene family
  
Possible biological names infered from orthology : P35278 / P51148
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 17615599
Gene end: 17651899
  
Corresponding Affymetrix probe sets: Dr.5030.1.S1_at (Zebrafish Array)   NM_201501_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000033828
Ensembl peptide - ENSDARP00000128672
Ensembl peptide - ENSDARP00000156922
NCBI entrez gene - 386807     See in Manteia.
RefSeq - NM_201501
RefSeq Peptide - NP_958909
swissprot - Q7ZVP2
swissprot - X1WEM1
ZFIN ID - ZDB-GENE-031118-30
Ensembl - ENSDARG00000026712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB5CENSGALG00000003359Gallus gallus
 RAB5CENSG00000108774Homo sapiens
 Rab5cENSMUSG00000019173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rab5aa / RAB5A, member RAS oncogene family, a / Rab5a* / Q9CQD1* / AC099811.2* / Ras-related protein Rab-5A *ENSDARG0000001860283
rab5ab / RAB5A, member RAS oncogene family, b / Rab5a* / Q9CQD1* / AC099811.2* / Ras-related protein Rab-5A *ENSDARG0000000725782
rab5b / RAB5B, member RAS oncogene familyENSDARG0000001605971
rab22a / RAB22A, member RAS oncogene family / P35285* / Q9UL26*ENSDARG0000001580743
LO018490.1 / RAB31* / Q13636* / RAB31, member RAS oncogene family*ENSDARG0000011583241
RAB21 / zgc:154045 / P35282* / Q9UL25* / RAB21, member RAS oncogene family*ENSDARG0000010075239
rab20 / RAB20, member RAS oncogene family / P35295* / Q9NX57* / Ras-related protein Rab-20 *ENSDARG0000000504933
Q6IMK3 / dnajc27 / DnaJ (Hsp40) homolog, subfamily C, member 27 / Q8CFP6* / Q9NZQ0* / DnaJ homolog subfamily C member 27 * / DnaJ heat shock protein family (Hsp40) member C27*ENSDARG0000007091625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0030100 regulation of endocytosis IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0030139 endocytic vesicle IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000029 hindbrain hindbrain distended , abnormal
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 ZFA:0000106 extension extension decreased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000109 forebrain forebrain morphology , abnormal
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 ZFA:0000135 notochord notochord cell malformed , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
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 ZFA:0000711 DEL DEL increased thickness , abnormal
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 ZFA:0001058 caudal fin caudal fin curved , abnormal
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 ZFA:0001079 blood vasculature blood vasculature broken , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased functionality , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014430 rabgef1 / RAB guanine nucleotide exchange factor (GEF) 1 / Q9JM13* / Q9UJ41* / AC027644.4* / Rab5 GDP/GTP exchange factor * / RAB guanine nucleotide exchange factor 1*  / complex
 ENSDARG00000038537 gga1 / golgi-associated, gamma adaptin ear containing, ARF binding protein 1 / Q8R0H9* / Q9UJY5* / ADP-ribosylation factor-binding protein GGA1 *  / complex
 ENSDARG00000051836 si:dkeyp-19e1.3 / B9A6J9* / TBC1D3* / P0C7X1* / Q2M2D7* / Q6DHY5* / Q6IPX1* / Q8IZP1* / Q86UD7* / A6NDS4* / TBC1D3H* / TBC1D3G* / TBC1D3I* / TBC1D3K* / TBC1D3L* / TBC1D26* / TBC1D28* / TBC1...  / complex / reaction
 ENSDARG00000011088 si:ch211-288d18.1 / B9A6J9* / TBC1D3* / P0C7X1* / Q2M2D7* / Q6DHY5* / Q6IPX1* / Q8IZP1* / Q86UD7* / A6NDS4* / TBC1D3H* / TBC1D3G* / TBC1D3I* / TBC1D3K* / TBC1D3L* / TBC1D26* / TBC1D28* / TB...  / complex / reaction
 ENSDARG00000098871 GGA3 (1 of many) / si:ch73-157i16.3 / GGA3* / Q9NZ52* / Q8BMI3* / ADP-ribosylation factor-binding protein GGA3 * / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex






 

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