ENSG00000111716


Homo sapiens

Features
Gene ID: ENSG00000111716
  
Biological name :LDHB
  
Synonyms : lactate dehydrogenase B / LDHB / P07195
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p12.1
Gene start: 21635342
Gene end: 21757857
  
Corresponding Affymetrix probe sets: 201030_x_at (Human Genome U133 Plus 2.0 Array)   213564_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442680
Ensembl peptide - ENSP00000379385
Ensembl peptide - ENSP00000379386
Ensembl peptide - ENSP00000398015
Ensembl peptide - ENSP00000229319
NCBI entrez gene - 3945     See in Manteia.
OMIM - 150100
RefSeq - XM_006719074
RefSeq - NM_001174097
RefSeq - NM_001315537
RefSeq - NM_002300
RefSeq Peptide - NP_001167568
RefSeq Peptide - NP_001302466
RefSeq Peptide - NP_002291
swissprot - F5H793
swissprot - Q5U077
swissprot - P07195
swissprot - A8MW50
swissprot - C9J7H8
Ensembl - ENSG00000111716
  
Related genetic diseases (OMIM): 614128 - [Lactate dehydrogenase-B deficiency], 614128
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldhbaENSDARG00000019644Danio rerio
 ldhbbENSDARG00000071076Danio rerio
 LDHBENSGALG00000035836Gallus gallus
 LdhbENSMUSG00000030246Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LDHA / P00338 / lactate dehydrogenase AENSG0000013433375
LDHC / P07864 / lactate dehydrogenase CENSG0000016679669
Q9BYZ2 / LDHAL6B / lactate dehydrogenase A like 6BENSG0000017198966
Q6ZMR3 / LDHAL6A / lactate dehydrogenase A like 6AENSG0000016680065
UEVLD / Q8IX04 / UEV and lactate/malate dehyrogenase domainsENSG0000015111639


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001557  L-lactate/malate dehydrogenase
 IPR011304  L-lactate dehydrogenase
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR018177  L-lactate dehydrogenase, active site
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0006090 pyruvate metabolic process TAS
 biological_processGO:0019674 NAD metabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004457 lactate dehydrogenase activity IEA
 molecular_functionGO:0004459 L-lactate dehydrogenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134333 LDHA / P00338 / lactate dehydrogenase A  / complex
 ENSG00000111716 LDHB / P07195 / lactate dehydrogenase B  / complex






 

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