ENSG00000113300


Homo sapiens

Features
Gene ID: ENSG00000113300
  
Biological name :CNOT6
  
Synonyms : CCR4-NOT transcription complex subunit 6 / CNOT6 / Q9ULM6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 180494412
Gene end: 180578405
  
Corresponding Affymetrix probe sets: 217970_s_at (Human Genome U133 Plus 2.0 Array)   222476_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481893
Ensembl peptide - ENSP00000261951
Ensembl peptide - ENSP00000377024
Ensembl peptide - ENSP00000422087
NCBI entrez gene - 57472     See in Manteia.
OMIM - 608951
RefSeq - XM_017009672
RefSeq - NM_001303241
RefSeq - XM_011534607
RefSeq - XM_017009670
RefSeq - XM_017009671
RefSeq - XM_005265953
RefSeq - XM_011534605
RefSeq - XM_011534606
RefSeq Peptide - NP_001290170
swissprot - Q9ULM6
swissprot - D6R9H6
Ensembl - ENSG00000113300
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot6aENSDARG00000008255Danio rerio
 cnot6bENSDARG00000101072Danio rerio
 CNOT6ENSGALG00000034316Gallus gallus
 Cnot6ENSMUSG00000020362Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNOT6L / Q96LI5 / CCR4-NOT transcription complex subunit 6 likeENSG0000013876778
ANGEL1 / Q9UNK9 / angel homolog 1ENSG0000001352322
PDE12 / Q6L8Q7 / phosphodiesterase 12ENSG0000017484021
ANGEL2 / Q5VTE6 / angel homolog 2ENSG0000017460620
NOCT / Q9UK39 / nocturninENSG0000015101418


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034966  CCR4-NOT transcription complex subunit 6
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035195 gene silencing by miRNA TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
 biological_processGO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:2000327 positive regulation of nuclear receptor transcription coactivator activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity IDA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
Activation of anterior HOX genes in hindbrain development during early embryogenesis
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198026 Q9H4Z2 / ZNF335 / zinc finger protein 335  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr