ENSG00000113492


Homo sapiens

Features
Gene ID: ENSG00000113492
  
Biological name :AGXT2
  
Synonyms : AGXT2 / alanine--glyoxylate aminotransferase 2 / Q9BYV1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.2
Gene start: 34998101
Gene end: 35048135
  
Corresponding Affymetrix probe sets: 229229_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000231420
Ensembl peptide - ENSP00000422799
Ensembl peptide - ENSP00000479154
NCBI entrez gene - 64902     See in Manteia.
OMIM - 612471
RefSeq - XM_017009748
RefSeq - NM_001306173
RefSeq - NM_031900
RefSeq - XM_005248337
RefSeq - XM_005248338
RefSeq Peptide - NP_001293102
RefSeq Peptide - NP_114106
swissprot - Q9BYV1
Ensembl - ENSG00000113492
  
Related genetic diseases (OMIM): 210100 - [Beta-aminoisobutyric acid, urinary excretion of], 210100
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agxt2ENSDARG00000100709Danio rerio
 AGXT2ENSGALG00000003432Gallus gallus
 Agxt2ENSMUSG00000089678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETNPPL / Q8TBG4 / ethanolamine-phosphate phospho-lyaseENSG0000016408931
PHYKPL / Q8IUZ5 / 5-phosphohydroxy-L-lysine phospho-lyaseENSG0000017530927


Protein motifs (from Interpro)
Interpro ID Name
 IPR005814  Aminotransferase class-III
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009436 glyoxylate catabolic process IDA
 biological_processGO:0019265 glycine biosynthetic process, by transamination of glyoxylate IDA
 biological_processGO:0019481 L-alanine catabolic process, by transamination IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0046487 glyoxylate metabolic process TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008453 alanine-glyoxylate transaminase activity TAS
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IBA
 molecular_functionGO:0042802 identical protein binding IBA
 molecular_functionGO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Pyrimidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113492 AGXT2 / Q9BYV1 / alanine--glyoxylate aminotransferase 2  / complex






 

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