ENSG00000115318


Homo sapiens

Features
Gene ID: ENSG00000115318
  
Biological name :LOXL3
  
Synonyms : LOXL3 / lysyl oxidase like 3 / P58215
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.1
Gene start: 74532414
Gene end: 74555690
  
Corresponding Affymetrix probe sets: 228253_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377512
Ensembl peptide - ENSP00000386545
Ensembl peptide - ENSP00000404026
Ensembl peptide - ENSP00000398260
Ensembl peptide - ENSP00000387103
Ensembl peptide - ENSP00000386696
Ensembl peptide - ENSP00000264094
NCBI entrez gene - 84695     See in Manteia.
OMIM - 607163
RefSeq - XM_017005112
RefSeq - NM_001289164
RefSeq - NM_001289165
RefSeq - NM_032603
RefSeq - XM_011533134
RefSeq Peptide - NP_115992
RefSeq Peptide - NP_001276093
RefSeq Peptide - NP_001276094
swissprot - B8ZZT6
swissprot - H7C248
swissprot - C9J5M1
swissprot - B9A025
swissprot - P58215
swissprot - E7END4
Ensembl - ENSG00000115318
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Loxl3ENSMUSG00000000693Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LOXL2 / Q9Y4K0 / lysyl oxidase like 2ENSG0000013401356
LOXL4 / Q96JB6 / lysyl oxidase like 4ENSG0000013813155
LOXL1 / Q08397 / lysyl oxidase like 1ENSG0000012903823
CD6 / P30203 / CD6 moleculeENSG0000001372518
LOX / P28300 / lysyl oxidaseENSG0000011308318
MARCO / Q9UEW3 / macrophage receptor with collagenous structureENSG0000001916910
MSR1 / P21757 / macrophage scavenger receptor 1ENSG0000003894510
Q6ZMJ2 / SCARA5 / scavenger receptor class A member 5ENSG000001680799


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001695  Lysyl oxidase
 IPR017448  SRCR-like domain
 IPR019828  Lysyl oxidase, conserved site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0018057 peptidyl-lysine oxidation IDA
 biological_processGO:0021510 spinal cord development ISS
 biological_processGO:0030324 lung development ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0061053 somite development ISS
 biological_processGO:1905590 fibronectin fibril organization ISS
 biological_processGO:2000329 negative regulation of T-helper 17 cell lineage commitment ISS
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001968 fibronectin binding ISS
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity NAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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