ENSG00000116128


Homo sapiens
beta-catenincomplexBCL9cellbindinglymphomadifferentiationskeletalmusclewntsignalingpathwaytranscriptionbeta-catenin-tcftransactivatingbb-celldomainmyotubeinvolvedregenerationsomaticstempopulationmaintenanceregulationrnapolymeraseiicanonicalassembly

Features
Gene ID: ENSG00000116128
  
Biological name :BCL9
  
Synonyms : B cell CLL/lymphoma 9 / BCL9 / O00512
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.2
Gene start: 147541412
Gene end: 147626216
  
Corresponding Affymetrix probe sets: 204129_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234739
NCBI entrez gene - 607     See in Manteia.
OMIM - 602597
RefSeq - XM_017002026
RefSeq - NM_004326
RefSeq - XM_005272971
RefSeq - XM_005277417
RefSeq - XM_005277418
RefSeq Peptide - NP_004317
swissprot - O00512
swissprot - A0A024QYY4
Ensembl - ENSG00000116128
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl9ENSDARG00000036687Danio rerio
 BCL9ENSGALG00000037655Gallus gallus
 Bcl9ENSMUSG00000038256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL9L / Q86UU0 / B cell CLL/lymphoma 9 likeENSG0000018617436


Protein motifs (from Interpro)
Interpro ID Name
 IPR015668  B Cell Lymphoma 9
 IPR024670  B-cell lymphoma 9, beta-catenin binding domain


Gene Ontology (GO)
response to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse to stressanatomical structure developmentcellular developmental processdevelopmental growthcell communicationcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesisresponse tresponse to stressanatomicalanatomical structure developmentcellular dcellular developmental processdevelopmendevelopmental growthcell commucell communicationcellular rcellular response to stimulusmaintenancmaintenance of cell numbernitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processcellular ccellular component organizationcellular ccellular component biogenesis
transcription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activitytranscription coregulator activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0014908 myotube differentiation involved in skeletal muscle regeneration IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005801 cis-Golgi network IDA
 cellular_componentGO:1990907 beta-catenin-TCF complex IPI
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / complex / reaction
 ENSG00000171016 PYGO1 / Q9Y3Y4 / pygopus family PHD finger 1  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000163348 PYGO2 / Q9BRQ0 / pygopus family PHD finger 2  / complex / reaction






 

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