ENSG00000148737


Homo sapiens

Features
Gene ID: ENSG00000148737
  
Biological name :TCF7L2
  
Synonyms : Q9NQB0 / TCF7L2 / transcription factor 7 like 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.2
Gene start: 112950250
Gene end: 113167678
  
Corresponding Affymetrix probe sets: 212759_s_at (Human Genome U133 Plus 2.0 Array)   212761_at (Human Genome U133 Plus 2.0 Array)   212762_s_at (Human Genome U133 Plus 2.0 Array)   216035_x_at (Human Genome U133 Plus 2.0 Array)   216037_x_at (Human Genome U133 Plus 2.0 Array)   216511_s_at (Human Genome U133 Plus 2.0 Array)   236094_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443626
Ensembl peptide - ENSP00000440547
Ensembl peptide - ENSP00000443883
Ensembl peptide - ENSP00000490478
Ensembl peptide - ENSP00000490260
Ensembl peptide - ENSP00000490004
Ensembl peptide - ENSP00000487507
Ensembl peptide - ENSP00000486891
Ensembl peptide - ENSP00000446238
Ensembl peptide - ENSP00000446172
Ensembl peptide - ENSP00000444972
Ensembl peptide - ENSP00000277945
Ensembl peptide - ENSP00000298692
Ensembl peptide - ENSP00000344823
Ensembl peptide - ENSP00000345640
Ensembl peptide - ENSP00000347949
Ensembl peptide - ENSP00000348274
Ensembl peptide - ENSP00000358393
Ensembl peptide - ENSP00000358396
Ensembl peptide - ENSP00000358402
Ensembl peptide - ENSP00000358404
Ensembl peptide - ENSP00000435694
NCBI entrez gene - 6934     See in Manteia.
OMIM - 602228
RefSeq - XM_017016596
RefSeq - XM_005270086
RefSeq - XM_005270088
RefSeq - XM_005270089
RefSeq - XM_005270091
RefSeq - XM_005270092
RefSeq - XM_005270093
RefSeq - XM_005270094
RefSeq - XM_005270095
RefSeq - XM_005270096
RefSeq - XM_005270100
RefSeq - XM_005270101
RefSeq - XM_005270102
RefSeq - XM_005270103
RefSeq - XM_005270104
RefSeq - XM_011540109
RefSeq - XM_011540110
RefSeq - XM_011540111
RefSeq - XM_011540113
RefSeq - XM_011540116
RefSeq - XM_017016584
RefSeq - XM_017016585
RefSeq - XM_017016586
RefSeq - XM_017016587
RefSeq - XM_017016588
RefSeq - XM_017016589
RefSeq - XM_017016590
RefSeq - XM_017016591
RefSeq - XM_017016592
RefSeq - XM_017016593
RefSeq - XM_017016594
RefSeq - XM_017016595
RefSeq - NM_001146274
RefSeq - NM_001146283
RefSeq - NM_001146284
RefSeq - NM_001146285
RefSeq - NM_001146286
RefSeq - NM_001198525
RefSeq - NM_001198526
RefSeq - NM_001198527
RefSeq - NM_001198528
RefSeq - NM_001198529
RefSeq - NM_001198530
RefSeq - NM_001198531
RefSeq - NM_030756
RefSeq - XM_005270071
RefSeq - XM_005270075
RefSeq - XM_005270077
RefSeq - XM_005270078
RefSeq - XM_005270079
RefSeq - XM_005270080
RefSeq - XM_005270084
RefSeq - XM_005270085
RefSeq Peptide - NP_001185459
RefSeq Peptide - NP_001185460
RefSeq Peptide - NP_110383
RefSeq Peptide - NP_001185458
RefSeq Peptide - NP_001139746
RefSeq Peptide - NP_001139755
RefSeq Peptide - NP_001139756
RefSeq Peptide - NP_001139757
RefSeq Peptide - NP_001139758
RefSeq Peptide - NP_001185454
RefSeq Peptide - NP_001185455
RefSeq Peptide - NP_001185456
RefSeq Peptide - NP_001185457
swissprot - Q5VVR7
swissprot - Q5VVR8
swissprot - Q6FHW4
swissprot - Q9NQB0
swissprot - A0A0A0MTL7
swissprot - Q5JRY5
swissprot - C6ZRK5
swissprot - C6ZRJ7
swissprot - C6ZRJ6
swissprot - A0A1B0GVE1
swissprot - A0A1B0GUV5
swissprot - A0A1B0GU84
swissprot - A0A0D9SGH8
swissprot - H0YEE5
swissprot - Q5JRY3
swissprot - Q5JRY4
swissprot - E2GH26
swissprot - Q5VVR5
Ensembl - ENSG00000148737
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, type 2, susceptibility to}, 125853

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf7l2ENSDARG00000004415Danio rerio
 TCF7L2ENSGALG00000008883Gallus gallus
 Q924A0ENSMUSG00000024985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9HCS4 / TCF7L1 / transcription factor 7 like 1ENSG0000015228460
LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1ENSG0000013879542
TCF7 / P36402 / transcription factor 7ENSG0000008105932


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009749 response to glucose ISS
 biological_processGO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0031016 pancreas development TAS
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032350 regulation of hormone metabolic process IDA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0043570 maintenance of DNA repeat elements IMP
 biological_processGO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046827 positive regulation of protein export from nucleus IMP
 biological_processGO:0048625 myoblast fate commitment IDA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:2000675 negative regulation of type B pancreatic cell apoptotic process ISS
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0070369 beta-catenin-TCF7L2 complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0045295 gamma-catenin binding IPI
 molecular_functionGO:0070016 armadillo repeat domain binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
TCF7L2 mutants dont bind CTBP
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124766 SOX4 / Q06945 / SRY-box 4  / complex / reaction
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / complex / reaction
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / complex / reaction
 ENSG00000164736 SOX17 / Q9H6I2 / SRY-box 17  / complex / reaction
 ENSG00000143842 SOX13 / Q9UN79 / SRY-box 13  / complex / reaction
 ENSG00000020633 RUNX3 / Q13761 / runt related transcription factor 3  / complex / reaction
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / complex / reaction
 ENSG00000116128 BCL9 / O00512 / B cell CLL/lymphoma 9  / complex / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000164362 TERT / O14746 / telomerase reverse transcriptase  / complex / reaction
 ENSG00000166477 LEO1 / Q8WVC0 / LEO1 homolog, Paf1/RNA polymerase II complex component  / complex / reaction
 ENSG00000171016 PYGO1 / Q9Y3Y4 / pygopus family PHD finger 1  / complex / reaction
 ENSG00000186174 BCL9L / Q86UU0 / B cell CLL/lymphoma 9 like  / complex / reaction
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / complex / reaction
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000196367 TRRAP / Q9Y4A5 / transformation/transcription domain associated protein  / complex / reaction
 ENSG00000127616 P51532 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000163348 PYGO2 / Q9BRQ0 / pygopus family PHD finger 2  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000134371 CDC73 / Q6P1J9 / cell division cycle 73  / complex / reaction
 ENSG00000087095 NLK / Q9UBE8 / nemo like kinase  / reaction






 

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