ENSG00000196781


Homo sapiens
regulationTLE1transcriptionwddomaincomplexdna-templatedwntsignalingbindingrepeatgrouchosuperfamily-repeat-containingpathwaybeta-catenin-tcfproteinbeta-catenintransactivatingtlen-terminalq-richtransducin-likeenhanceryvtnrepeat-like-containingconservedsiternapolymeraseii

Features
Gene ID: ENSG00000196781
  
Biological name :TLE1
  
Synonyms : Q04724 / TLE1 / transducin like enhancer of split 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q21.32
Gene start: 81583683
Gene end: 81689305
  
Corresponding Affymetrix probe sets: 1553569_at (Human Genome U133 Plus 2.0 Array)   1553570_x_at (Human Genome U133 Plus 2.0 Array)   203220_s_at (Human Genome U133 Plus 2.0 Array)   203221_at (Human Genome U133 Plus 2.0 Array)   203222_s_at (Human Genome U133 Plus 2.0 Array)   227130_s_at (Human Genome U133 Plus 2.0 Array)   228284_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365646
Ensembl peptide - ENSP00000365667
Ensembl peptide - ENSP00000365682
Ensembl peptide - ENSP00000391347
NCBI entrez gene - 7088     See in Manteia.
OMIM - 600189
RefSeq - XM_017015066
RefSeq - NM_001303103
RefSeq - NM_001303104
RefSeq - NM_005077
RefSeq - XM_006717260
RefSeq - XM_006717261
RefSeq - XM_006717262
RefSeq - XM_006717263
RefSeq - XM_011518951
RefSeq - XM_017015064
RefSeq - XM_017015065
RefSeq - XM_005252151
RefSeq - XM_005252152
RefSeq - XM_005252153
RefSeq - XM_005252154
RefSeq - XM_005252156
RefSeq - XM_005252162
RefSeq - XM_005252163
RefSeq - XM_006717258
RefSeq - XM_006717259
RefSeq Peptide - NP_001290032
RefSeq Peptide - NP_001290033
RefSeq Peptide - NP_005068
swissprot - Q04724
swissprot - Q5T3G2
swissprot - Q5T3G3
swissprot - F6T2C8
Ensembl - ENSG00000196781
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE1ENSGALG00000012575Gallus gallus
 Tle1ENSMUSG00000008305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4 / Q04727 / transducin like enhancer of split 4ENSG0000010682987
TLE3 / Q04726 / transducin like enhancer of split 3ENSG0000014033280
TLE2 / Q04725 / transducin like enhancer of split 2ENSG0000006571767
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG0000010495319
TLE7 / transducin like enhancer of split family member 7ENSG0000026073418
AES / Q08117 / amino-terminal enhancer of splitENSG0000010496417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusanatomical structure developmentcellular component organizationcellular component biogenesiscell deathnitrogen comnitrogen compound metabolic processbiosyntheticbiosynthetic processcellular metcellular metabolic processprimary metaprimary metabolic processorganic subsorganic substance metabolic processcell communicell communicationcellular rescellular response to stimulusanatomical sanatomical structure developmentcellular comcellular component organizationcellular comcellular component biogenesiscell deathcell death
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IMP
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000104964 AES / Q08117 / amino-terminal enhancer of split  / complex / reaction
 ENSG00000114315 HES1 / Q14469 / hes family bHLH transcription factor 1  / complex / reaction
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / complex / reaction






 

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