ENSGALG00000012575


Gallus gallus

Features
Gene ID: ENSGALG00000012575
  
Biological name :TLE1
  
Synonyms : TLE1 / transducin like enhancer of split 1
  
Possible biological names infered from orthology : Q04724 / Q62440 / Transducin-like enhancer protein 1
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 39184187
Gene end: 39254335
  
Corresponding Affymetrix probe sets: GgaAffx.7983.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020507
Ensembl peptide - ENSGALP00000054719
Ensembl peptide - ENSGALP00000051985
NCBI entrez gene - 427450     See in Manteia.
RefSeq - XM_015280364
RefSeq - XM_004949181
RefSeq - XM_015280362
RefSeq - XM_015280363
RefSeq - XM_003643035
swissprot - A0A1D5PPC0
swissprot - A0A1D5PGR2
swissprot - E1C492
Ensembl - ENSGALG00000012575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE1ENSG00000196781Homo sapiens
 Tle1ENSMUSG00000008305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *ENSGALG0000001518487
TLE3 / transducin like enhancer of split 3 / Q04726* / Q08122*ENSGALG0000000812071
ENSGALG0000003397140
ENSGALG0000004227528
ENSGALG0000003272414
AES / amino-terminal enhancer of split / P63002* / Q08117*ENSGALG0000002950312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / complex / reaction
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / reaction
 ENSGALG00000008491 XIAP / BIRC8* / P98170* / Q60989* / Q96P09* / X-linked inhibitor of apoptosis* / baculoviral IAP repeat containing 8*  / complex / reaction
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000031960 LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*  / complex / reaction






 

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