ENSG00000123338


Homo sapiens
regulationNCKAP1Lcelldifferentiationmembraneactivitytproteinbhomeostasisneutrophilactinpathwaychemotaxiserythrocytereceptorsignalingcomplexproliferationkinaseinterleukin-productionphagocytosisdegranulationcd-positivealpha-betagtpaseprotein-containingplasmaintegral

Features
Gene ID: ENSG00000123338
  
Biological name :NCKAP1L
  
Synonyms : NCKAP1L / NCK associated protein 1 like / P55160
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 54497711
Gene end: 54548238
  
Corresponding Affymetrix probe sets: 209734_at (Human Genome U133 Plus 2.0 Array)   217549_at (Human Genome U133 Plus 2.0 Array)   238668_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445596
Ensembl peptide - ENSP00000293373
Ensembl peptide - ENSP00000447246
NCBI entrez gene - 3071     See in Manteia.
OMIM - 141180
RefSeq - NM_005337
RefSeq - NM_001184976
RefSeq Peptide - NP_001171905
RefSeq Peptide - NP_005328
swissprot - P55160
swissprot - F8W050
Ensembl - ENSG00000123338
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCKAP1LENSDARG00000075748Danio rerio
 Q8K1X4ENSMUSG00000022488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCKAP1 / Q9Y2A7 / NCK associated protein 1ENSG0000006167658


Protein motifs (from Interpro)
Interpro ID Name
 IPR019137  Nck-associated protein 1


Gene Ontology (GO)
regulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulation of biological qualityresponse to external stimulusresponse to chemicalestablishment or maintenance of cell polaritylocalization of cellmovement of cell or subcellular componentcellular response to stimuluscellular component organizationcellular component biogenesisactin filament-based processcell activationleukocyte proliferationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcytokine productioncell adhesionimmune responsecell communicationestablishment of localizationimmune effector processcell deathanatomical structure developmentcellular developmental processregulregulation of biological qualityresporesponse to external stimulusresporesponse to chemicalestabestablishment or maintenance of cell polaritylocallocalization of cellmovemmovement of cell or subcellular componentcellucellular response to stimuluscellucellular component organizationcellucellular component biogenesisactinactin filament-based processcell cell activationleukoleukocyte proliferationnitronitrogen compound metabolic processcellucellular metabolic processprimaprimary metabolic processregulregulation of molecular functionorganorganic substance metabolic processcytokcytokine productioncell cell adhesionimmunimmune responsecell cell communicationestabestablishment of localizationimmunimmune effector processcell cell deathanatoanatomical structure developmentcellucellular developmental process
enzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityprotein bindingprotein-containing complex bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein bindingprotein-containing complex bindingprotein-containing complex binding
cellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellcellmembranemembraneorganelleorganelleprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis ISS
 biological_processGO:0002262 myeloid cell homeostasis ISS
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0030011 maintenance of cell polarity IMP
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0030866 cortical actin cytoskeleton organization ISS
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production ISS
 biological_processGO:0032715 negative regulation of interleukin-6 production ISS
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin ISS
 biological_processGO:0034101 erythrocyte homeostasis ISS
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IMP
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043029 T cell homeostasis ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
 biological_processGO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045579 positive regulation of B cell differentiation ISS
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation ISS
 biological_processGO:0045621 positive regulation of lymphocyte differentiation ISS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048821 erythrocyte development IEP
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment ISS
 biological_processGO:0065003 protein-containing complex assembly ISS
 biological_processGO:0070358 actin polymerization-dependent cell motility IMP
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031209 SCAR complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030295 protein kinase activator activity IMP
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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